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Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:downregulated_F120_vs_F30
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Proteins that are enriched in productive tract of adult female Brugia malayi. |
Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction. |
WBPaper00048706:productive-tract_enriched
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Transcripts that showed significantly increased expression after 48 hours of 100nM ivermectin exposure. |
Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). |
WBPaper00049974:ivermectin_100nM_48h_upregulated
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Time-course transcript abundance profiles. P116, k-means clusters of Brugia malayi during development in Aedes aegypti LVP between day 1 and 8 post infection; H114, k-means clusters of Ae. aegypti LVP infected with B. malayi between day 0 and 8 post infection; and HR14, host response profile comparing infected vs. uninfected A. aegypti LVP. |
Non-flat profiles (p < 0.01 and maximum fold-difference among time points > 2) were grouped into common temporal patterns using k-means clustering. |
WBPaper00045439:BM_Cluster_P2
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