WormMine: Gene WBGene00224753

• WormBase Gene ID: WBGene00224753
• Gene Name: Bma-lgl-1
• Sequence Name: Bm4492
• Organism: Brugia malayi
• Automated Description: Is affected by 20-hydroxyecdysone based on proteomic studies. Is predicted to encode a protein with the following domains: Quinoprotein alcohol dehydrogenase-like superfamily; Lethal(2) giant larvae protein; WD40-repeat-containing domain superfamily; WD40/YVTN repeat-like-containing domain superfamily; WD domain, G-beta repeat; WD40 repeat; LLGL2; and Lethal giant larvae homologue 2. Is an ortholog of C. elegans lgl-1. In C. elegans, lgl-1 is involved in establishment of spindle orientation and protein localization.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm4492.1	Bm4492.1		[unknown]

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm4492	Bm4492		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

• WormBaseAcedbConverter

0 Downstream Intergenic Region

3 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_F120
	Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M120_vs_M30
	Proteins that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone.	An empirical filter of proteins with more than two peptides identified, a P value <0.05 and a greater than two-fold change of differential expression, was applied to the data. The Bonferroni correction was applied to correct the P value for the proteins analyzed.	WBPaper00049261:20-hydroxyecdysone_upregulated_protein

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term