WormMine: Gene WBGene00226918

• WormBase Gene ID: WBGene00226918
• Gene Name: Bm6657
• Sequence Name: Bm6657
• Organism: Brugia malayi
• Automated Description: Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: C-type lectin-like; C-type lectin-like/link domain superfamily; Lectin C-type domain; and C-type lectin fold. Is an ortholog of O. volvulus OVOC143.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

3 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm6657a.1	Bm6657a.1		[unknown]
Transcript:Bm6657b.1	Bm6657b.1		[unknown]
Transcript:Bm6657c.1	Bm6657c.1		[unknown]

Other

3 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm6657c	Bm6657c		[unknown]
CDS:Bm6657b	Bm6657b		[unknown]
CDS:Bm6657a	Bm6657a		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

• WormBaseAcedbConverter

0 Downstream Intergenic Region

5 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_F120
	Transcripts that showed significantly lower expression in adult comparing to in microfilariae.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:Adult_vs_Micro_Downregulated
	Transcripts that showed significantly higher expression in L4 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Adult_Upregulated
	Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_F120_vs_F30
	Transcripts that showed significantly decreased expression after 48 hours of 100nM ivermectin exposure.	Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method).	WBPaper00049974:ivermectin_100nM_48h_downregulated

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term