WormMine: Gene WBGene00224695

• WormBase Gene ID: WBGene00224695
• Gene Name: Bm4434
• Sequence Name: Bm4434
• Organism: Brugia malayi
• Automated Description: Is affected by ivermectin based on RNA-seq studies. Is predicted to encode a protein with the following domains: Immunoglobulin E-set; AMP-activated protein kinase, glycogen-binding domain; 5'-AMP-activated protein kinase beta subunit, interaction domain; ASC domain superfamily; Immunoglobulin-like fold; Association with the SNF1 complex (ASC) domain; and Glycogen recognition site of AMP-activated protein kinase. Is an ortholog of C. elegans aakb-1 and aakb-2.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

2 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm4434a.1	Bm4434a.1		[unknown]
Transcript:Bm4434b.1	Bm4434b.1		[unknown]

Other

2 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm4434b	Bm4434b		[unknown]
CDS:Bm4434a	Bm4434a		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

1 Data Sets

• WormBaseAcedbConverter

0 Downstream Intergenic Region

4 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_F120_vs_F30
	Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M30_vs_L4
	Transcripts that showed significantly decreased expression in female B. malayi 30 days after infecting gerbils, comparing to L4 female B. malayi animals.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_F30_vs_L4
	Transcripts that showed significantly increased expression after 48 hours of 100nM ivermectin exposure.	Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method).	WBPaper00049974:ivermectin_100nM_48h_upregulated

0 Expression Patterns

0 GO Annotation

0 Homologues

0 Locations

0 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term