Is predicted to encode a protein with the following domains: E3 ubiquitin-protein ligase synoviolin/Hrd1; Ring finger domain; Zinc finger, RING-type; and Zinc finger, RING/FYVE/PHD-type. Is an ortholog of C. elegans sel-11 and uvs-1. In C. elegans, uvs-1 is involved in response to UV and transcription-coupled nucleotide-excision repair.