WormBase Gene ID
|
RGD:68332 | Gene Name | Pde1c |
| Organism | Rattus norvegicus | Automated Description | Enables cAMP binding activity; calmodulin-activated 3',5'-cyclic-GMP phosphodiesterase activity; and calmodulin-activated dual specificity 3',5'-cyclic-GMP, 3',5'-cyclic-AMP phosphodiesterase activity. Involved in negative regulation of insulin secretion involved in cellular response to glucose stimulus. Acts upstream of or within response to calcium ion. Located in neuronal cell body. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 74. Orthologous to human PDE1C (phosphodiesterase 1C); PARTICIPATES IN protein kinase A (PKA) signaling pathway; calcium/calcium-mediated signaling pathway; purine metabolic pathway; INTERACTS WITH alpha-Zearalanol; ammonium chloride; bisphenol A. |
| Biotype | SO:0001217 | Genetic Position | :± |
