WormBase Gene ID
|
RGD:3590 | Gene Name | Rock2 |
| Organism | Rattus norvegicus | Automated Description | Predicted to enable Rho-dependent protein serine/threonine kinase activity; endopeptidase activator activity; and protease binding activity. Involved in several processes, including positive regulation of cardiac muscle hypertrophy; positive regulation of connective tissue replacement; and positive regulation of cytokine production. Acts upstream of or within Rho protein signal transduction. Predicted to be located in cytoplasmic ribonucleoprotein granule; cytosol; and spindle pole centrosome. Predicted to be active in several cellular components, including Schaffer collateral - CA1 synapse; glutamatergic synapse; and postsynaptic density. Orthologous to human ROCK2 (Rho associated coiled-coil containing protein kinase 2); PARTICIPATES IN chemokine mediated signaling pathway; transforming growth factor-beta superfamily mediated signaling pathway; Wnt signaling pathway; INTERACTS WITH 1,3,5-trinitro-1,3,5-triazinane; 17beta-estradiol; 2,3,7,8-tetrachlorodibenzodioxine. |
| Biotype | SO:0001217 | Genetic Position | :± |
