| Primary Identifier | Expr9094 | Remark | Picture: Fig 2, Fig S1. |
| Subcellular Localization | The SMC-6 protein was detected by indirect immunofluorescence microscopy in the nuclei of germ cells throughout the adult hermaphrodite gonad. Beginning at the distal tip region of the gonad, SMC-6 staining is detected in the nucleus of germ cells in mitotic proliferation, pre-meiotic S phase and in the early stages of meiosis (the transition zone), which are equivalent to leptotene and zygotene. SMC-6 staining became more enriched on chromosomes at pachytene, which coincided with the timing of meiotic DSB repair. The SMC-6 immunofluorescence became more intense as the germ cells exited pachytene and progressed through the diplotene and diakinesis stages of prophase. The pachytene and diakinesis staining of SMC-6 was specifically disrupted by the smc-6(ok3294) mutation. In addition to germ cell staining, immunostaining was detected in somatic cells during early embryogenesis. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes. | germ line | germline | WBbt:0005784 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00010056 | smc-6 | F54D5.14 | Caenorhabditis elegans |
