1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003047 | lis-1 | T03F6.5 | Caenorhabditis elegans |
| Primary Identifier | Expr3077 | Subcellular Localization | LIS-1 is present throughout the cytoplasm, but is also enriched in discrete subcellular locations. In early one-cell-stage embryos, LIS-1 is typically detected within pronuclei during late prophase, before NEBD would be apparent by DIC microscopy. In favourable specimens, LIS-1 can also be detected at the nuclear periphery during late prophase (two-cell-stage embryo) as well as in the vicinity of chromosomes during prometaphase. LIS-1 is depleted from the centres of microtubule asters during prometaphase, whereas it is enriched throughout the spindle during metaphase and early anaphase. During late anaphase and telophase, LIS-1 staining diminishes on the spindle but becomes enriched in the vicinity of the microtubule asters. Moreover, LIS-1 enrichment becomes apparent at the cell cortex at this stage. The discrete subcellular distributions of LIS-1 are typically more readily detectable in subsequent cell cycles. This is especially true of the nuclear enrichment in prophase, of the spindle enrichment in metaphase and of the cortical localization. Whereas foci of LIS-1 colocalize with the plus end of some astral microtubules, this is not always the case, and many LIS-1 foci are found throughout the microtubule lattice. Therefore, C. elegans LIS-1 is not detected strictly at the plus end of microtubules. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00003047 | lis-1 | T03F6.5 | Caenorhabditis elegans |
