1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004215 | ptp-3 | C09D8.1 | Caenorhabditis elegans |
| Primary Identifier | Expr3650 | Subcellular Localization | PTP-3B::GFP showed a temporally regulated expression, with high expression throughout embryogenesis and larval development until the L1-L2 larval transition. In the adult nervous system, PTP-3B::GFP was present in the nerve ring and along axons of the ventral and dorsal nerve cords and was also observed in the pharyngeal epithelium and the developing uterus throughout development. Most of the PTP-3B::GFP was adjacent to the UNC-10 puncta, with only a small amount of GFP overlapping with UNC-10. PTP-3A::GFP expression was first detected around the 2-fold stage of embryonic development (450 min after fertilization) in the nerve ring and nerve cords and continued at a constant level through larval development. PTP-3A::GFP was seen in a punctate pattern along nerve processes and overlapped with UNC-10 in a pattern that was similar to the endogenous protein. These results suggest that PTP-3A is the major isoform that is localized to presynaptic domains. Consistent with this conclusion, in ptp-3A(ok244) mutant animals, <25% of the UNC-10 puncta (n = 200) contained any PTP-3, and the amount of PTP-3 present at those UNC-10 puncta was reduced. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00004215 | ptp-3 | C09D8.1 | Caenorhabditis elegans |
