WormMine: AnatomyTerm WBbt:0005759

• Definition: neuron that senses external stimuli and transduce them to signals internal to the organism.
• Name: sensory neuron
• Primary Identifier: WBbt:0005759

15 Children

Definition	Name	Synonym	Primary Identifier
neuron in the male ray.	ray neuron		WBbt:0006971
neuron that senses soluable chemicals	chemosensory neuron		WBbt:0005837
Sensory neuron of copulatory spicule in male, cilliated, open to outside at tip of spicule.	spicule neuron	SP neuron	WBbt:0005831
Hook sensory neurons.	HO neuron		WBbt:0005177
Neuron class of four male-specific neurons associated with cephalic sensilla.	CEM		WBbt:0005246
Neuron that senses and responds to oxygen.	oxygen sensory neuron		WBbt:0008432
neuron that senses and responds to mechanical stimuli, such as touch.	mechanosensory neuron		WBbt:0008431
Male-specific neuron of the post-cloacal sensillum.	PC neuron		WBbt:0005473
neuron that senses changes of CO2 concentration in the environment.	carbon dioxide sensory neuron	CO2 sensory neuron	WBbt:0008430
neuron that senses volatile odorants	odorsensory neuron		WBbt:0005839
neuron that senses temperature	thermosensory neuron		WBbt:0005838
neuron that senses and responds to changes in osmolarity in the environment.	osmosensory neuron		WBbt:0008433
neuron that senses pain.	nociceptor neuron		WBbt:0008434
Neuron class of four neurons with cell bodies situated anterior to the nerve ring. presynaptic in ring, non-ciliated endings in head, associated with OLQ in embryo	URY		WBbt:0005346
Neuron class of two neurons with cell bodies situated in the lumbar ganglia. Posteriorly directed processes run from the cell bodies into the tails pike running alongside the processes of PLM and PLN. The disposition of these processes suggests that they may be sensory dendrites.	PHC		WBbt:0008446

2 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly depleted expression in sensory neuron (labeled by iaIs25[Pgcy-37::GFP + unc-119(+)]) comparing to in whole worm.	Fold change > 2, p-value < 0.05.	WBPaper00060661:sensory-neuron_depleted
	Transcripts that showed significantly increased expression in sensory neuron (labeled by iaIs25[Pgcy-37::GFP + unc-119(+)]) comparing to in whole worm.	Fold change > 2, p-value < 0.05.	WBPaper00060661:sensory-neuron_enriched

134 Expression Patterns

• Primary Identifier: Expr4976
• Remark: Picture: Figure 4A and supplemental Table S1.
• Pattern: OCR-2 reporter expression was found in sensory neurons. These sensory neurons have no known role in egg laying. In addition, OCR-2 reporter was expressed in cells of the egg-laying system. These were the four uterus-associated uv1 cells attached to the ventral surface of the uterus, as well as the syncytial uv1-associated cell utse. In adults, OCR-2 reporter expression was much stronger in uv1 than in utse; in larval animals, it was the reverse.

• Primary Identifier: Expr4545
• Remark: asna-1 has been predicted to be the fourth gene in an operon together with the genes ZK637.2, ZK637.3, and ZK637.4 according to WS160.
• Pattern: In worms carrying the transgene, GFP expression was seen in a subset of sensory neurons, in the intestine, and, more weakly, in the hypodermis.

• Primary Identifier: Expr4546
• Remark: asna-1 has been predicted to be the fourth gene in an operon together with the genes ZK637.2, ZK637.3, and ZK637.4 according to WS160.
• Pattern: An ASNA-1::GFP fusion protein driven by the 430 bp fragment fully rescued asna-1(sv42) and asna-1(ok938). In worms carrying the transgene, like those harboring the longer construct, GFP expression was seen in a restricted set of sensory neurons, in the intestine, and weakly in the hypodermis. Further analysis of the sensory neuron expression revealed that during the L1 and L2 stages, GFP was invariably expressed in ASI, and often also in ASK. In some animals, expression was also seen in ADL; however, in most animals expression was not seen in all three pairs of neurons simultaneously.

• Primary Identifier: Expr10103
• Remark: Promoter::GFP fusion constructs of variable lengths were generated using PCR amplification followed by subsequent cloning into expression vectors.
• Pattern: Expressed in both the amphid and tail ciliated sensory neurons. The 60 C. elegans CSNs present in an adult hermaphrodite worm were divided into 5 subgroups or anatomical regions including, neurons that reside in the amphids (region 1 = 24 CSNs: AWAL/R, AWBL/R, AWCL/R, AFDL/R, ASEL/R, ADFL/R, ASGL/R, ASHL/R, ASIL/R, ASJLR, ASKL/R, ADLL/R) or in the tail (region 2 = 5 CSNs: PHAL/R, PHBL/R, PQR), neurons surrounding the anterior bulb (region 3 = 24 CSNs: BAGL/ R, CEPVL/R, CEPDL/R, IL1L/R, IL2L/R, IL1VL/R, IL2VL/R, IL1DL/R, IL2DL/R, OLLL/R, OLQVL/R, OLQDL/R) or the posterior bulb (region 4 = 5 CSNs: ADEL/R, FLPL/R, AQR) of the pharynx, and neurons in the midbody region of the worm (region 5=2 CSNs: PDEL/R). ift-20 was detected in all 5 regions.

• Primary Identifier: Expr8268
• Remark: Picture: Fig. 1, A and C; Table 1.
• Pattern: Expression of SHL-1 was observed in posterior intestine, body wall muscle, vulval muscle, male-specific diagonal muscles, and a variety of motor neurons, interneurons, and sensory neurons.

• Primary Identifier: Expr10114
• Remark: Promoter::GFP fusion constructs of variable lengths were generated using PCR amplification followed by subsequent cloning into expression vectors.
• Pattern: Expressed in both the amphid and tail ciliated sensory neurons. The 60 C. elegans CSNs present in an adult hermaphrodite worm were divided into 5 subgroups or anatomical regions including, neurons that reside in the amphids (region 1 = 24 CSNs: AWAL/R, AWBL/R, AWCL/R, AFDL/R, ASEL/R, ADFL/R, ASGL/R, ASHL/R, ASIL/R, ASJLR, ASKL/R, ADLL/R) or in the tail (region 2 = 5 CSNs: PHAL/R, PHBL/R, PQR), neurons surrounding the anterior bulb (region 3 = 24 CSNs: BAGL/ R, CEPVL/R, CEPDL/R, IL1L/R, IL2L/R, IL1VL/R, IL2VL/R, IL1DL/R, IL2DL/R, OLLL/R, OLQVL/R, OLQDL/R) or the posterior bulb (region 4 = 5 CSNs: ADEL/R, FLPL/R, AQR) of the pharynx, and neurons in the midbody region of the worm (region 5=2 CSNs: PDEL/R). ift-139 was detected in all 5 regions.

• Primary Identifier: Expr10053
• Pattern: The nhr-239::gfp reporter was weakly expressed in three to four pairs of neurons in the head and a pharyngeal neuron in late stage embryos and all larval and adult stages. One pair of dorsal neurons express nhr-239::gfp very consistently and appear to be sensory, as do one pair of pharyngeal cells that appear to be the MC, NSM or M3 neurons.Faint fluorescence was observed in the pharynx (which may be an artefact), but did not observe nhr-239 expression in other cells at any stage. As expected from the modest expression levels observed in qRT-PCR experiments, fluorescence from the nhr-239::gfp transgene was very faint. While it is possible that the translational fusion did not recapitulate the entire nhr-239 expression pattern, this result suggests that nhr-239 is expressed only in a very limited subset of neurons. nhr-239 transcripts were identified by real-time qRT-PCR at very low levels (no more than 2x10-6 the level of 18 S rRNA standards) and displayed a more complicated pattern, increasing somewhat from embryos to L1, before declining progressively during later larval development.

• Primary Identifier: Expr10104
• Remark: Promoter::GFP fusion constructs of variable lengths were generated using PCR amplification followed by subsequent cloning into expression vectors.
• Pattern: Expressed in both the amphid and tail ciliated sensory neurons. The 60 C. elegans CSNs present in an adult hermaphrodite worm were divided into 5 subgroups or anatomical regions including, neurons that reside in the amphids (region 1 = 24 CSNs: AWAL/R, AWBL/R, AWCL/R, AFDL/R, ASEL/R, ADFL/R, ASGL/R, ASHL/R, ASIL/R, ASJLR, ASKL/R, ADLL/R) or in the tail (region 2 = 5 CSNs: PHAL/R, PHBL/R, PQR), neurons surrounding the anterior bulb (region 3 = 24 CSNs: BAGL/ R, CEPVL/R, CEPDL/R, IL1L/R, IL2L/R, IL1VL/R, IL2VL/R, IL1DL/R, IL2DL/R, OLLL/R, OLQVL/R, OLQDL/R) or the posterior bulb (region 4 = 5 CSNs: ADEL/R, FLPL/R, AQR) of the pharynx, and neurons in the midbody region of the worm (region 5=2 CSNs: PDEL/R). tza-1 was detected in all 5 regions.

• Primary Identifier: Expr3681
• Remark: The differences in the expression patterns of Pmbr-1::gfp and mbr-1::gfp might be due to the following reasons: first, additional regulatory elements might exist in introns and 3$(B!l(B-UTR regions, which are not included in the former construct; and second, as the product of Pmbr-1::gfp diffuses throughout the cytoplasm, it might be difficult to detect low levels of GFP expression.
• Pattern: In strains that carry Pmbr-1::gfp, GFP expression was observed in restricted sets of interneurons in the head ganglia: AIM, RIC, RIH (or RIR), RIF (or RIG), and a pair of interneurons tentatively identified as AIN. Expression was also observed in three interneurons of the tail ganglia: PVP and an interneuron tentatively identified as DVA or DVC. In contrast, mbr-1::gfp was expressed in several more neurons compared to Pmbr-1::gfp, including sensory neurons. Expression of mbr-1::gfp was also detected in some intestinal cells at the late embryonic stages as well as in vulval cells and some somatic gonadal cells at the L4 stage. mbr-1::gfp expression becomes detectable first around the early comma stage, which corresponds to the time just after the birth of most neurons.
• Subcellular Localization: The MBR-1::GFP fusion protein was localized to the nuclei, consistent with the idea that MBR-1 functions as a transcription factor.

• Primary Identifier: Expr14174
• Remark: Other Strain: OH14363
• Pattern: 3 head sensory neuron pairs, PHA, PHB, glia

• Primary Identifier: Expr10124
• Remark: Promoter::GFP fusion constructs of variable lengths were generated using PCR amplification followed by subsequent cloning into expression vectors.
• Pattern: Expressed in both the amphid and tail ciliated sensory neurons. The 60 C. elegans CSNs present in an adult hermaphrodite worm were divided into 5 subgroups or anatomical regions including, neurons that reside in the amphids (region 1 = 24 CSNs: AWAL/R, AWBL/R, AWCL/R, AFDL/R, ASEL/R, ADFL/R, ASGL/R, ASHL/R, ASIL/R, ASJLR, ASKL/R, ADLL/R) or in the tail (region 2 = 5 CSNs: PHAL/R, PHBL/R, PQR), neurons surrounding the anterior bulb (region 3 = 24 CSNs: BAGL/ R, CEPVL/R, CEPDL/R, IL1L/R, IL2L/R, IL1VL/R, IL2VL/R, IL1DL/R, IL2DL/R, OLLL/R, OLQVL/R, OLQDL/R) or the posterior bulb (region 4 = 5 CSNs: ADEL/R, FLPL/R, AQR) of the pharynx, and neurons in the midbody region of the worm (region 5=2 CSNs: PDEL/R). nph-4 was detected in all 5 regions.

• Primary Identifier: Expr11583
• Pattern: Paakg-5::GFP is expressed in the female gonad sheath cells, vulva epithelium and neurons, ventral cord neurons and excretory cell. It is also seen in the spermatheca and epithelial seam cells. In addition to the excretory cell, Paakg-5::GFP displays strong expression levels in the pharyngeal epithelia, neurons, some ring neurons and sensory neuron termini. In the tail, Paakg- 5::GFP signal mostly localizes to the pre-anal ganglion, rectum epithelium, intestinal-rectal valve and phasmid support cells. For a summary of Paakg-5::GFP see table S10.

• Primary Identifier: Expr12805
• Pattern: C10C6.7 expression is visible in nine cells: interneuron RIS; pharyngeal neurons M1, M2, Motor-interneuron, an unidentified pair of pharyngeal neurons and an unidentified pair of sensory neurons.

• Primary Identifier: Expr9156
• Remark: Picture: Fig. 3c, Fig S4a, to S4c.
• Pattern: grld-1 was expressed in many cell types, including, muscles, epithelial cells and neurons. Coexpressing mCherry under the opt-3 promoter, grld-1 was found expressed in AVE. grld-1 was also expressed in many of the neurons that are important for the nose-touch behavior, including the A-type motor neurons, the sensory neuron, ASH, and the glr-1expressing interneurons AVA and AVD.

• Primary Identifier: Expr15543
• Pattern: In adult C. elegans, nhr-66 is broadly expressed, including hypodermis, gut, muscle, and neuronal cells of the ventral nerve chord, head, and tail ganglia. In the head ganglion, several sensory and interneurons, including AVA, express NHR-66. Interestingly, global nhr-66 expression was not altered with age.

• Primary Identifier: Expr294
• Remark: Data modified according to Shawn Lockery's expression pattern curations.
• Pattern: Expressed in URX, ALA, some sensory neurons, interneurons, pharyngeal neurons and muscle.

• Primary Identifier: Expr9428
• Pattern: The expression pattern of the predicted calcineurin B was similar to the pattern of tax-6::gfp in pAK43. See Expr1824: pAK43 drove TAX-6 expression in many sensory neurons, as well as interneurons including AIY and AIZ, and most, if not all, muscle cells.
• Subcellular Localization: Scattered and distinct cytoplasmic signals of CNB-1 was observed surrounding the cellularized spermatids. Sub-cellular localization within the body wall muscle: Dense bodies, Thick filaments and/or M-line, SR/ER Wildtype male sperm was examined and immunostained with antiCNB-1 antibody. As expected, robust staining was observed in the wild-type sperm and the staining was distinctly cytoplasmic.

• Primary Identifier: Expr7995
• Remark: Picture: Figure 2B and 2C.
• Pattern: Motor neurons in the ventral nerve cord, and sensory- and interneurons in the nerve ring and in the tail, were labelled. Expression was also observed in muscles and hypodermal cells.

• Primary Identifier: Expr10832
• Pattern: osta-1 gfp expression was observed exclusively in all ciliated sensory neurons in the head amphid and tail phasmid organs, with occasional expression in other neurons. Expression was observed at late embryonic stages and was maintained throughout postembryonic development.

• Primary Identifier: Expr11704
• Pattern: Expression of the transcriptional fusion Ptop-1::gfp was not detected in early embryonic cells due to maternal germline silencing of the multi-copy transgenic gene. The GFP expression, however, was observed in most cells at the late embryonic stage and decreased with larval development. In the larval stages, GFP expression was predominantly present in the neuronal system, including sensory neurons (ILso, URX, RIC, IL1/IL2, AIY/AIM and RIG/RIF), motor neurons (VC4, VC5, HSN, PVD and PVM) of hermaphrodites and tail neurons (SPD and SPV/SPC) of males. The expression of the transcriptional fusion Ptop-1::gfp was strong in DTCs during the L3-L4 stage when gonad migration proceeds.

• Primary Identifier: Expr16179
• Pattern: The irk-3 translational fusion was not tolerated by the worms, even at low doses. Hence, a transcriptional fusion was used to assess the extent of irk-3 gene expression. Irk-3 promoter activity was limited to neurons, but it was broadly expressed throughout multiple neuronal subtypes, including sensory neurons and the HSN. It is interesting that irk gene expression was notably absent in muscle and hypodermal cells.

• Primary Identifier: Expr14100
• Remark: Other Strain: OH13854
• Pattern: ASK, ASI, 1 bright sensory pair in front of ASK, sometimes ASJ, a couple more dim pairs, sometives PVT

• Primary Identifier: Expr10838
• Remark: Supplemental Table S4.

• Primary Identifier: Expr10849
• Remark: Supplemental Table S4.

• Primary Identifier: Expr10854
• Remark: Supplemental Table S4.

• Primary Identifier: Expr10860

• Primary Identifier: Expr10861

• Primary Identifier: Expr10867

• Primary Identifier: Expr10874

• Primary Identifier: Expr10877

0 Life Stages

1 Parents

Definition	Name	Synonym	Primary Identifier
Major cell type of nervous tissue, specialized for transmission of information in the form of patterns of impulses.	neuron	neurone	WBbt:0003679