WormMine: ExpressionPattern Expr1737

• Pattern: SET-2L protein is localized in the nuclei of all cells in embryos at all stages of embryogenesis. In L1 larvae, SET-2L remains visible in the nuclei of most cell types but is most prominent in Z2 and Z3, the primordial germ cells. In adults, SET-2L staining is nuclear and is strongest in the germline, although it is also detectable in other cell types, such as intestinal, pharyngeal, and neuronal cells. The level of SET-2L varies in different portions of the gonad. It is present in the distal mitotic cells, diminishes to very low levels in the transition zone and early pachytene regions, and increases dramatically in mid-pachytene nuclei. In oocytes, the level of SET-2L appears relatively low.
• Primary Identifier: Expr1737
• Remark: The specificity of the antibodies was demonstrated by the observation that SET-2L immunostaining is reduced to below detection in set-2(RNAi) embryos and worms. Ubiquitous. The specificity of the antibodies was demonstrated by the observation that SET-2L immunostaining is reduced to below detection in set-2(RNAi) embryos and worms.
• Subcellular Localization: nuclei

6 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
A chain of very large cuboidal cells forming a wide central lumen in which food arrives from the posterior pharynx, is digested, and from which waste products proceed to the rectum. Intestinal rings form in groups of two and four cells surrounding the common lumen; thus the epithelium is only one cell deep at any point, with neighboring cells firmly secured to their neighbors by apical adherens junctions. These cells have very large nuclei and many large vacuoles, yolk granules, and other inclusions; the latter increase in number and electron density as the animal ages.	intestine	gut	WBbt:0005772
the feeding organ, a neuro-muscular pump in the head of the animal, used to ingest food, bacteria suspended in liquid, filter them out, grind them up and transport posteriorly into the instestine.	pharynx	esophagus	WBbt:0003681
a cellular object that consists of subcellular components, expresses genes or functions.	Cell	Cell type	WBbt:0004017
cell line which early in development becomes differentiated from the remaining somatic cell line, and alone has the potential to undergo meiosis and form gametes.	germ line	germline	WBbt:0005784
Germ line precursor cell	Z3	lineage name: P4.a	WBbt:0004575
Germ line precursor cell	Z2	lineage name: P4.p	WBbt:0004576

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004782	set-2	C26E6.9	Caenorhabditis elegans

3 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	The first stage larva. At 25 Centigrade, it ranges 14-25.5 hours after fertilization, 0-11.5 hours after hatch.		L1 larva Ce	WBls:0000024
	The stage that begins when a C.elegans individual is fully-developed and has reached maturity.		adult Ce	WBls:0000041
	The whole period of embryogenesis in the nematode Caenorhabditis elegans, from the formation of an egg until hatching.		embryo Ce	WBls:0000003