| Primary Identifier | Expr7871 | Remark | Picture: Fig. 6A. Fig. 7A-C, Fig. 8A,B. The staining pattern of CSQ-1 looked very similar, if not identical, to that of UNC-68 antibody staining, which also showed a mesh-like pattern, in addition to punctate staining, in body-wall muscle cells. |
| Subcellular Localization | A mesh-like staining was observed in the body-wall muscle cells. Co-staining with MH24: The mesh-like signals of CSQ-1 (red) overlapped with the punctate vinculin signals (green/yellow). Although the double-labeling of body-wall muscles with anti-CSQ-1 and anti-vinculin show that both the proteins are localized around the same areas, the strong mesh-like staining of CSQ-1 spanning the muscle bands indicates that CSQ-1 is expressed over a wider range in the myofilament lattice. Immunogold electron microscopy: In body-wall muscle cells of wild-type animals, CSQ-1 signals were observed in the cytoplasmic regions of muscle cells, at sarcoplasmic membranes surrounding myofibril bundles, and also at spaces between sarcomeric bundles, where the dense body structures could be observed . Clustered signals were observed at the apical SR membranes juxtaposed to the basement membranes. These regions of flattened SR-like vesicles have already been reported to be the sites for the localization of RYR (UNC-68), suggesting that CSQ-1 may be localized at the SR membranes in the regions where RYR are located. |
| Definition | Name | Synonym | Primary Identifier |
|---|---|---|---|
| Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion. | body wall musculature | body muscle | WBbt:0005813 |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000822 | csq-1 | F40E10.3 | Caenorhabditis elegans |
