WormMine: ExpressionPattern Expr11357

• Pattern: CATP-6::GFP is expressed in multiple tissues throughout development. These include a) many neurons in the head and tail, b) all body muscles, c) most pharyngeal cells, particularly in the posterior bulb, d) vulval muscles, e) coelomocytes, f) spermatheca, g) gonadal sheath cells, and h) lateral hypodermis.
• Primary Identifier: Expr11357
• Subcellular Localization: In many cases, particularly neurons, the fusion protein localizes to cytoplasmic puncta that probably correspond to membranous vesicles. In other tissues, e.g., pharyngeal cells and gonadal sheath cells, CATP-6::GFP is closely associated with the plasma membrane. Most significantly with regard to the effect of catp-6(0) on gonadogenesis, CATP-6::GFP is associated with the plasma membrane of the somatic gonad precursor cells, Z1 and Z4. Although the authors detect CATP-6::GFP in close association with the plasma membrane in some tissues, they cannot certain that the protein is actually located within the plasma membrane. For example, in the case of Z1 and Z4 the fluorescence pattern of CATP-6::GFP (unlike that of GEM-1::GFP) is often discontinuous along the periphery of the cell. Thus, it remains possible that the protein localizes to vesicles that are just beneath the plasma membrane. Furthermore, it is possible that CATP-6 localizes to both plasma membrane and vesicular compartments and that the relative distribution differs between cell types. Higher resolution microscopy will be necessary to resolve this issue.

12 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
an accordion-like tube that contains sperm and is the site of oocyte fertilization.	spermatheca		WBbt:0005319
Longitudinal bands of muscle cells surrounding animal body, with one band running in each quadrant of the body, regulated contraction and relaxation of these muscles cause locomotion.	body wall musculature	body muscle	WBbt:0005813
muscle associated with hermaphrodite vulva.	vulval muscle		WBbt:0005821
neuron with its cell body situated in the head, excluding the pharynx.	head neuron		WBbt:0006751
neuron with its cell body situated in the tail, posterior to rectum.	tail neuron		WBbt:0006759
a group of hypodermal cells that lie along the apical midline of the hypodermis, at the extreme left and right sides between nose and tail	seam cell	lateral hypodermis	WBbt:0005753
	pharyngeal cell		WBbt:0005460
A free-floating spherical cell lying in the pseudocoelomic cavity of larvae and adult C. elegans which can endocytose many compounds, possibly for immune surveillance. There are six coelomocytes in adult hermaphrodites, and they display prominent cytoplasmic inclusions and vacuoles.	coelomocyte		WBbt:0005751
five pairs of thin gonadal sheath cells form a single layer covering the germ line component of each arm, each pair occupying a stereotyped position along the gonad proximal-distal axis.	gonadal sheath cell		WBbt:0005828
Somatic gonad precursor cell	Z1	lineage name: MSpppaap	WBbt:0004577
Somatic gonad precursor cell	Z4	lineage name: MSappaap	WBbt:0004574
the last, posterior bulb of the pharynx.	terminal bulb		WBbt:0003732

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00012341	catp-6	W08D2.5	Caenorhabditis elegans

0 Life Stages