WormMine: ExpressionPattern Expr962

• Pattern: Expression was observed in the hermaphrodite DTCs and MLCs as well as in all five classes of motorneurons that exhibit axon guidance defects in unc-5 mutants (DA, DB, DD, VD, AS). In addition, expression was observed in several classes of neurons in the head that are not visibly affected by unc-5 mutations. These included 12 sensory neurons of the OLQ, OLL and IL2 classes, and the interneurons RIA, RIH and ASE. Expression of lacZ or gfp transcriptional reporters in the DA, DB and DD embryonic motorneurons was first detected in late stage embryos at about the time when these neurons are known to extend pioneer axons along the epidermis (aka, hypodermis) to the dorsal side. Expression in the DA and DB neurons was transient, and only DD staining persisted into larval and adult stages. The VD motorneurons expressed intensely at this and at later times, while the AS neurons expressed faintly and sporadically.
• Primary Identifier: Expr962
• Remark: This 4.6 kb fragment contains sufficient regulatory sequence to rescue cell migration and axon guidance phenotypes of unc-5 mutants when fused to an unc-5 cDNA (Hamelin et al., 1993; M.-W. S. and J.G.C., unpublished data).

25 Anatomy Terms

Definition	Name	Synonym	Primary Identifier
Posterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad	posterior distal tip cell	gon herm dtc P	WBbt:0004506
Anterior distal tip cell, inhibit meiosis in neighbouring germ cells, lead gonad during morphogenesis, herm gonad	anterior distal tip cell	gon herm dtc A	WBbt:0004520
male gonad cell, leads gonad during morphogenesis and initiates union with cloaca	linker cell	gon_male_link	WBbt:0005062
Neuron class of nine ventral cord motor neuron, innervates dorsal muscle.	DA neuron		WBbt:0005278
Neuron class of seven motoneurons that innervate dorsal muscles and have cell bodies in the ventral cord.	DB neuron		WBbt:0005274
Neuron class of six motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles. Each cell has a short, posteriorly directed and a longer, anteriorly directed process emanating from its cell body. The anterior process has a branch, which leaves the ventral cord as a commissure and runs round to the dorsal cord.	DD neuron		WBbt:0005270
Neuron class of thirteen motoneurons, with cell bodies in the ventral cord, which innervate ventral muscles. Each cell has an anteriorly directed process emanating from its cell body.	VD neuron		WBbt:0005303
Neuron class of eleven motoneurons, with cell bodies in the ventral cord, which innervate dorsal muscles.	AS neuron		WBbt:0005334
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil	ASEL	lineage name: ABalppppppaa	WBbt:0003904
one member of Amphid neurons, single ciliated endings, probably chemo-sensory; project into ring via commissure from ventral ganglion, make diverse synaptic connections in ring neuropil	ASER	lineage name: ABpraaapppaa	WBbt:0003903
Lateral outer labial neurons	OLLL	lineage name: ABalppppapaa	WBbt:0004445
Lateral outer labial neurons	OLLR	lineage name: ABpraaapapaa	WBbt:0004444
Ring interneuron, many synapses	RIAL	lineage name: ABalapaapaa	WBbt:0003960
Ring interneuron, many synapses	RIAR	lineage name: ABalaapppaa	WBbt:0003958
Quadrant outer labial neuron	OLQVL	lineage name: ABplpaaappaa	WBbt:0004437
Quadrant outer labial neuron	OLQVR	lineage name: ABprpaaappaa	WBbt:0004431
Quadrant outer labial neuron	OLQDL	lineage name: ABalapapapaa	WBbt:0004439
Quadrant outer labial neuron	OLQDR	lineage name: ABalapppapaa	WBbt:0004438
Inner labial neuron	IL2VR	lineage name: ABarapppppp	WBbt:0004537
Inner labial neuron	IL2DR	lineage name: ABalappppap	WBbt:0004543
Inner labial neuron	IL2L	lineage name: ABalapaappp	WBbt:0004541
Inner labial neuron	IL2R	lineage name: ABalaappppp	WBbt:0004539
Inner labial neuron	IL2VL	lineage name: ABalppapppp	WBbt:0004538
Inner labial neuron	IL2DL	lineage name: ABalapappap	WBbt:0004545
Neuron class of one ring interneuron.	RIH	lineage name: ABprpappaaa	WBbt:0003928

1 Genes

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006745	unc-5	B0273.4	Caenorhabditis elegans

1 Life Stages

Remark	Definition	Other Name	Public Name	Primary Identifier
	All C. elegans development stages, including embryo, larva and adult stage.		all stages Ce	WBls:0000002