1 Genes
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000249 | bir-1 | T27F2.3 | Caenorhabditis elegans |
| Primary Identifier | Expr1077 | Remark | No detailed description on cellular localization. |
| Subcellular Localization | BIR-1 immunoreactivity was first detected on prometaphase chromosomes and persisted on these chromosomes at the metaphase plate. BIR-1 staining overlapped with DNA rather than with the kinetochore, as determined by triple-staining with DAPI and antibodies against BIR-1 and HCP-1. During anaphase, BIR-1 was present both on chromosomes and the spindle midzone. During telophase, BIR-1 immunoreactivity was no longer detectable on decondensing DNA but was still present on the spindle midzone. Following cytokinesis, BIR-1 staining persisted at the cytokinetic remnant. A similar pattern of immunoreactivity was observed within cells during subsequent divisions. BIR-1 was also present during meiosis. In hermaphrodite oocytes, BIR-1 first became visible on the condensed chromosomes of the oocyte most proximal to the spermatheca. BIR-1 localization to chromosomes in this oocyte required sperm in the spermatheca and either preceded or was concomitant with nuclear envelope breakdown. BIR-1 was also associated with meiotic chromosomes in spermatocytes but was not associated with DNA in mature sperm or condensed paternal DNA following fertilization. Following fertilization, BIR-1 remained localized to condensed maternal chromosomes during metaphase I and was found associated with chromosomes as well as the spindle midzone during anaphase I. During metaphase II, BIR-1 was seen associated with polar body DNA and the sister chromatids. BIR-1 was again associated with both polar body DNA and the spindle midzone during anaphase II. |
| WormBase Gene ID | Gene Name | Sequence Name | Organism |
|---|---|---|---|
| WBGene00000249 | bir-1 | T27F2.3 | Caenorhabditis elegans |
