WormMine: RNAi WBRNAi00088791

• WormBase ID: WBRNAi00088791
• Phenotype Remark: let-92(RNAi) embryos fail to properly align their chromosomes on a metaphase plate and display defects in mitotic exit such as failure to reform nuclei and to decondense chromatin.
• Remark: let-92 RNAi

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00002363	let-92	F38H4.9	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:F38H4.9	F38H4.9	957	IV: 11858446-11858574

1 Laboratories

Primary Identifier
OC

9 Phenotype

Identifier	Name	Description
WBPhenotype:0000318	cell cycle delayed	Cells of the animals proceed through their replicative phase at a pace slower than observed for control cells.
WBPhenotype:0000746	cell division variant	Any variation that alters the physical partitioning and separation of a cell into daughter cells compared to control.
WBPhenotype:0001350	protein phosphorylation increased	Animals exhibit higher levels of protein phosphorylation compared to that observed in control animals.
WBPhenotype:0001139	nuclear envelope assembly variant early emb	Nuclear envelope does not reassemble properly.
WBPhenotype:0001903	centrosome biogenesis variant	Animals exhibit variations in the formation, maturation or disassembly of the centrosome (a subcellular body consisting of two centrioles embedded in a protein matrix). The centrosome serves as a microtubule organizing center as well as a regulator of cell-cycle progression.
WBPhenotype:0001102	mitotic spindle defective early emb	Early embryos exhibit defects in the assembly, disassembly, arrangement, elongation or stabilization of the microtubule spindle during a mitotic cell cycle.
WBPhenotype:0001584	chromosome alignment variant	Any variation in the movement of chromosomes to the spindle equator during mitosis compared to control animals.
WBPhenotype:0001876	centriole biogenesis variant	Any variation in the formation or disassembly of the cylindrical structures that are composed of groupings of microtubules found close to the nucleus (centrioles) compared to control. Centrioles are arranged perpendicularly and are surrounded by an amorphous mass of dense material (the pericentriolar material). The centrioles and the pericentriolar material constitute the compound structure known as the centrosome.
WBPhenotype:0002061	chromosome decondensation variant	Any variation in the progressive decompaction of chromatin that changes chromosome structure from the condensed form to a relaxed disperse form.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00038325

0 Strain