WormMine: RNAi WBRNAi00077612

• WormBase ID: WBRNAi00077612
• Genotype: cul-4(gk434)
• Phenotype Remark: The size of seam cell nuclei in cki-1(RNAi) cul-4(gk434) larvae was reduced approximately threefold relative to cul-4(gk434) larvae and the seam cell DNA level was reduced. This indicates that cki-1 RNAi depletion suppresses the rereplication phenotype of cul-4 mutants. Significantly, the cki-1(RNAi) cul-4(gk434) larvae still accumulated CDT-1 protein in seam cells indicating that CKI-1 is not required for the accumulation of CDT-1 and that CDT-1 accumulation is not sufficient to induce extensive rereplication.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00000516	cki-1	T05A6.1	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:T05A6.1	T05A6.1	555	II: 7811259-7811467

1 Laboratories

Primary Identifier
ET

2 Phenotype

Identifier	Name	Description
WBPhenotype:0000732	DNA metabolism variant	Variations in any process that involves the maintenance, biosynthesis or accumulation of DNA in the organism compared to control.
WBPhenotype:0001567	nuclei enlarged	Nuclei of specific cells are larger compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00028868

0 Strain