WormMine: RNAi WBRNAi00093854

• WormBase ID: WBRNAi00093854
• Genotype: let-7(n2853)
• Phenotype Remark: Depletion of xrn-2 increases mature miRNA levels and activity. Authors examined RNA from L4-stage let-7(n2853) worms, northern blotting revealed that xrn-2(RNAi) increased mature let-7 levels. In addition, depletion of xrn-2 extended to wild-type let-7 and unrelated miRNAs, supporting a broad function of XRN-2 in miRNA homeostasis.
• Remark: Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

2 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00006964	xrn-2	Y48B6A.3	Caenorhabditis elegans
WBGene00220169	Y48B6A.25	Y48B6A.25	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y48B6A.3	Y48B6A.3	2928	II: 14155787-14156074

1 Laboratories

Primary Identifier
HW

1 Phenotype

Identifier	Name	Description
WBPhenotype:0001779	miRNA expression variant	Variations in the biogenesis or stability of the microRNA class of molecules compared to control. In C. elegans these molecules are endogenous single-stranded regulatory molecules, 19-25 nucleotides long, with the potential to arise from hairpin, foldback, structures from their primary transcripts.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00035168

0 Strain