WormMine: RNAi WBRNAi00097407

• WormBase ID: WBRNAi00097407
• Phenotype Remark: Worms depleted of p170 ifg-1 mRNA (construct N2) showed relatively normal somatic body size and morphology, but produced few late stage oocytes and no viable embryos. While mitotic and early meiotic nuclei appeared normal, the lack of condensed chromosomes following the diplotene stage suggested that oocytes did not complete diakinesis. All ifg-1(RNAi) worms displayed marked deterioration in the proximal gonad.
• Remark: (Figure 4b, 4c) ifg-1 RNAi (construct N2)

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00002066	ifg-1	M110.4	Caenorhabditis elegans

5 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:M110.4b	M110.4b	3468	II: 8217254-8217302
CDS:M110.4d	M110.4d	3480	II: 8217254-8217302
CDS:M110.4e	M110.4e	3483	II: 8217254-8217302
CDS:M110.4a	M110.4a	3471	II: 8217254-8217302
CDS:M110.4c	M110.4c	3129	II: 8217839-8218837

1 Laboratories

Primary Identifier
KX

6 Phenotype

Identifier	Name	Description
WBPhenotype:0000154	reduced brood size	The characteristic number of offspring produced is lower compared to that of control animals.
WBPhenotype:0000050	embryonic lethal	Animals die during embryonic development. In C. elegans, often assayed as refractile eggs that fail to hatch; when applied to large-scale RNAi screens in C. elegans, more than 10% of embryos die.
WBPhenotype:0000229	small	Animals are shorter and thinner than control animals at the same developmental stage.
WBPhenotype:0001944	oocyte number decreased	A decreased number of celullarized haploid female germ cells (oocytes) are present in the gonad compared to control.
WBPhenotype:0001948	diakinesis progression during oogenesis variant	Developing oocytes show defects in their entry, progression through or exit from the diakinesis stage compared to control animals. Diakinesis is a cell cycle process comprising the steps by which a cell progresses through the final stage of prophase I in meiosis; the transition to meiotic metaphase I.
WBPhenotype:0001958	gonad degenerate	Animals contain a gonad that initially functioned, but subsequently stopped. In hermaphrodites or females there is often the presence old embryos and/or hatched larva, but no young embryos, in the uterus.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00031847

0 Strain