WormMine: RNAi WBRNAi00084797

• WormBase ID: WBRNAi00084797
• Genotype: unc-54(r293) smg-1(cc546); rrf-3(pk1426)
• Phenotype Remark: smg-2 RNAi results in an accumulation of rpl-12 mRNA transcripts containing a premature termination codon, indicating a reduced activity of the nonsense mediated decay pathway
• Remark: Exact sequence used for RNAi not stated by authors, Ahringer laboratory clone used for curation.

1 Organism

• Name: Caenorhabditis elegans
• Taxon Id: 6239

1 Data Sets

• WormBaseAcedbConverter

1 Inhibits Gene

WormBase Gene ID	Gene Name	Sequence Name	Organism
WBGene00004880	smg-2	Y48G8AL.6	Caenorhabditis elegans

1 Inhibits Predicted Gene

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Y48G8AL.6	Y48G8AL.6	3210	I: 1176475-1176621

0 Laboratories

2 Phenotype

Identifier	Name	Description
WBPhenotype:0001538	mRNA surveillance defective	Defects in the cellular machinery that targets aberrant mRNAs species (nonsense codons, splice errors, altered untranslated regions etc.) for degradation. In C. elegans, mutations in such loci often act as allele-specific non gene-specific recessive suppressors of certain allele phenotypes and cause abnormal morphogenesis of male and hermaphrodite genitalia.
WBPhenotype:0000508	nonsense mRNA accumulation	Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail.

0 Phenotype _ Not _ Observed

1 Reference

First Author	Title	Year	Journal	Volume	Pages	PubMed ID
						WBPaper00037111

0 Strain