WormMine

WS294

Intermine data mining platform for C. elegans and related nematodes

RNAi :

WormBase ID  WBRNAi00111075 Phenotype Remark  Hypersensitivity to graphene oxide as assayed by lifespan reduction and increased ROS production compared to control animals. After graphene oxide addition, RNAi of mpk-1 resulted in the formation of more severe reduction in lifespan and the more significant induction of ROS production compared with wild-type nematodes. Authors later show that germline-specific RNAi knock-down of mpk-1using rrf-1(pk1417) did not significantly affect the susceptibility to graphene oxide (GO). These results imply that the neuronal MPK-1 may play a crucial role in regulating the response to GO exposure.
Remark  Exact sequence used for RNAi not stated by authors, spliced coding region sequence of gene used for curation.
Paste the following link
Lists
This RNAi isn't in any lists. Upload a list.

1 Organism

Name Taxon Id
Caenorhabditis elegans 6239

1 Data Sets

Name URL
WormBaseAcedbConverter  

1 Inhibits Gene

WormBase Gene ID Gene Name Sequence Name Organism
WBGene00003401 mpk-1 F43C1.2 Caenorhabditis elegans

2 Inhibits Predicted Gene

WormMine ID Sequence Name Length (nt) Chromosome Location
CDS:F43C1.2a F43C1.2a 1131   III: 4217396-4217615
CDS:F43C1.2b F43C1.2b 1335   III: 4217396-4217615

0 Laboratories

1 Phenotype

Identifier Name Description
WBPhenotype:0001918 chemical hypersensitive Animals respond to a specific chemical at a lower concentration or a shorter exposure compared to control animals.

0 Phenotype _ Not _ Observed

1 Reference

First Author Title Year Journal Volume Pages PubMed ID
            WBPaper00051025

0 Strain