WormMine: OntologyRelation

• Relationship: is_a
• Parent Term . Identifier: DOID:0081065
• Child Term . Identifier: DOID:0081070
• Direct: true
• Redundant: false

1 Child Term

• Identifier: DOID:0081070
• Name: EZB-MYC+ diffuse large B-cell lymphoma
• Description: An EZB diffuse large B-cell lymphoma that expresses the double hit gene expression signature (DHITsig+) according to gene expression profiling. In addition to the features characteristic of EZB, these cases commonly, but do not always, harbour MYC translocations and DDX3X mutations.

1 Parent Term

• Identifier: DOID:0081065
• Name: EZB diffuse large B-cell lymphoma
• Description: A diffuse large B-cell lymphoma that is categorized as EZB with high probability by the LymphGen algorithm. This is based on a combination of genetic features and EZB DLBCLs often, but do not always, have hot spot mutations in EZH2 and/or a BCL2 translocation. This class can be further subdivided into two sub-classes EZB-MYC+ and EZB-MYC- using the double hit gene expression signature (DHITsig). This subgroup also commonly has mutations due to aberrant somatic hypermutation affecting IRF8, which can be coding or non-coding.