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Proteins that are enriched in productive tract of adult female Brugia malayi. |
Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction. |
WBPaper00048706:productive-tract_enriched
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Transcripts that showed significantly decreased expression after 48 hours of 100nM ivermectin exposure. |
Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). |
WBPaper00049974:ivermectin_100nM_48h_downregulated
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Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:upregulated_F120_vs_F30
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Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:downregulated_M120_vs_M42
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Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils. |
EdgeR(v3.16.5), FDR < 0.05. |
WBPaper00051007:upregulated_M120_vs_F120
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Time-course transcript abundance profiles. P116, k-means clusters of Brugia malayi during development in Aedes aegypti LVP between day 1 and 8 post infection; H114, k-means clusters of Ae. aegypti LVP infected with B. malayi between day 0 and 8 post infection; and HR14, host response profile comparing infected vs. uninfected A. aegypti LVP. |
Non-flat profiles (p < 0.01 and maximum fold-difference among time points > 2) were grouped into common temporal patterns using k-means clustering. |
WBPaper00045439:BM_Cluster_P12
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Transcripts that showed significantly decreased expression at L3 day 6 animals comparing to L3 Day 9 worms. |
Differential gene expression analysis was performed using both DESeq and EdgeR, and the overlapping genes with FDR<0.01 were retained. |
WBPaper00059852:B.malayi_L3Day6_downregulated_vs_L3Day9
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