WormMine: Gene WBGene00229106

• WormBase Gene ID: WBGene00229106
• Gene Name: Bm8845
• Sequence Name: Bm8845
• Organism: Brugia malayi
• Automated Description: Predicted to enable GTP binding activity. Predicted to be a structural constituent of cytoskeleton. Predicted to be involved in microtubule-based process. Predicted to be located in microtubule. Is an ortholog of C. elegans tba-7; tbb-1; and tbb-2.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

2 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm8845b.1	Bm8845b.1		[unknown]
Transcript:Bm8845a.1	Bm8845a.1		[unknown]

Other

2 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm8845a	Bm8845a		[unknown]
CDS:Bm8845b	Bm8845b		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

2 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set

0 Downstream Intergenic Region

11 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly lower expression in adult comparing to in microfilariae.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:Adult_vs_Micro_Downregulated
	Proteins that are enriched in productive tract of adult female Brugia malayi.	Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction.	WBPaper00048706:productive-tract_enriched
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_M30
	Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_F120_vs_F30
	Transcripts that showed significantly lower expression in L4 larva comparing to in microfilariae.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Micro_Downregulated
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_M42
	Transcripts that showed significantly increased expression in female B. malayi 120 days after infecting gerbils, comparing to 42 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_F120_vs_F42
	Transcripts that showed significantly increased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M120_vs_F120
	Transcripts that showed significantly increased expression in male B. malayi 30 days after infecting gerbils, comparing to L4 male B. malayi animals.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:upregulated_M30_vs_L4
	Transcripts that showed significantly increased expression after 48 hours of 1uM ivermectin exposure.	Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method).	WBPaper00049974:ivermectin_1uM_48h_upregulated
	Transcripts that showed significantly lower expression in L4 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Adult_Downregulated

0 Expression Patterns

4 GO Annotation

0 Homologues

0 Locations

4 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term