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Transcripts that showed significantly higher expression in L3 larva comparing to in adult. |
edgeR v3.28. FDR < 0.05, fold change > 2. |
WBPaper00061765:L3_vs_Adult_Upregulated
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Proteins that are enriched in productive tract of adult female Brugia malayi. |
Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction. |
WBPaper00048706:productive-tract_enriched
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Transcripts that showed significantly decreased expression after 5 days of 1uM ivermectin exposure. |
Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). |
WBPaper00049974:ivermectin_1uM_5-day_downregulated
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Proteins secreted by B.malayi at L3 larva stage, according to LC-MS-MS. |
N.A. |
WBPaper00050454:Secretome_protein
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Transcripts that showed significantly decreased expression after 48 hours of 300nM ivermectin exposure. |
Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method). |
WBPaper00049974:ivermectin_300nM_48h_downregulated
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Time-course transcript abundance profiles. P116, k-means clusters of Brugia malayi during development in Aedes aegypti LVP between day 1 and 8 post infection; H114, k-means clusters of Ae. aegypti LVP infected with B. malayi between day 0 and 8 post infection; and HR14, host response profile comparing infected vs. uninfected A. aegypti LVP. |
Non-flat profiles (p < 0.01 and maximum fold-difference among time points > 2) were grouped into common temporal patterns using k-means clustering. |
WBPaper00045439:BM_Cluster_P15
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