WormMine: Gene WBGene00232826

• WormBase Gene ID: WBGene00232826
• Gene Name: Bma-scc-2
• Sequence Name: Bm12565
• Organism: Brugia malayi
• Automated Description: Predicted to enable chromatin binding activity. Predicted to be involved in mitotic cohesin loading and regulation of gene expression. Is an ortholog of C. elegans scc-2. In C. elegans, scc-2 is involved in several processes, including chromosome organization; double-strand break repair involved in meiotic recombination; and regulation of cell cycle process.
• Biotype: SO:0001217
• Genetic Position: :±

1 Organism

• Name: Brugia malayi
• Taxon Id: 6279

0 Synonyms

Genomics

1 Transcripts

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
Transcript:Bm12565.1	Bm12565.1		[unknown]

Other

1 CDSs

WormMine ID	Sequence Name	Length (nt)	Chromosome Location
CDS:Bm12565	Bm12565		[unknown]

0 RNAi Result

0 Allele

0 Chromosome

0 Chromosome Location

2 Data Sets

• WormBaseAcedbConverter
• GO Annotation data set

0 Downstream Intergenic Region

8 Expression Clusters

Regulated By Treatment	Description	Algorithm	Primary Identifier
	Transcripts that showed significantly decreased expression in male B. malayi 120 days after infecting gerbils, comparing to female B. malayi 120 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_M120_vs_F120
	Transcripts that showed significantly higher expression in L3 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L3_vs_Adult_Upregulated
	Transcripts that showed significantly higher expression in L4 larva comparing to in adult.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Adult_Upregulated
	Transcripts that showed significantly decreased expression in female B. malayi 120 days after infecting gerbils, comparing to 30 days after infecting gerbils.	EdgeR(v3.16.5), FDR < 0.05.	WBPaper00051007:downregulated_F120_vs_F30
	Transcripts that showed significantly higher expression in L4 larva comparing to in microfilariae.	edgeR v3.28. FDR < 0.05, fold change > 2.	WBPaper00061765:L4_vs_Micro_Upregulated
	Proteins that are enriched in productive tract of adult female Brugia malayi.	Protein quantitation was determined by normalized spectral abundance.Proteins with NSAF enrichment values of 2 or greater were were considered enriched within that fraction.	WBPaper00048706:productive-tract_enriched
	Proteins that showed significantly increased expression in parasites exposed to 20-hydroxyecdysone.	An empirical filter of proteins with more than two peptides identified, a P value <0.05 and a greater than two-fold change of differential expression, was applied to the data. The Bonferroni correction was applied to correct the P value for the proteins analyzed.	WBPaper00049261:20-hydroxyecdysone_upregulated_protein
	Transcripts that showed significantly decreased expression after 48 hours of 300nM ivermectin exposure.	Differential gene expression analysis between time points and drug concentrations was realized in edgeR (version 3.10.5) through the web interface provided by NetworkAnalyst. Significance was set as an experiment-wide false discovery rate (FDR) <0.20 (after the Benjamini-Hochberg method).	WBPaper00049974:ivermectin_300nM_48h_downregulated

0 Expression Patterns

3 GO Annotation

0 Homologues

0 Locations

3 Ontology Annotations

0 Regulates Expr Cluster

0 Sequence

1 Sequence Ontology Term