WormMine: GOTerm GO:0001734 mRNA m(6)A methyltransferase activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

2 Ontology Annotations

11 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016740	transferase activity	Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0140640	catalytic activity, acting on a nucleic acid	Catalytic activity that acts to modify a nucleic acid.
GO:0140098	catalytic activity, acting on RNA	Catalytic activity that acts to modify RNA.
GO:0016741	transferase activity, transferring one-carbon groups	Catalysis of the transfer of a one-carbon group from one compound (donor) to another (acceptor).
GO:0008757	S-adenosylmethionine-dependent methyltransferase activity	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a substrate.
GO:0008173	RNA methyltransferase activity	Catalysis of the transfer of a methyl group from a donor to a nucleoside residue in an RNA molecule.
GO:0008168	methyltransferase activity	Catalysis of the transfer of a methyl group to an acceptor molecule.
GO:0008174	mRNA methyltransferase activity	Catalysis of the transfer of a methyl group from S-adenosyl-L-methionine to a nucleoside residue in an mRNA molecule.
GO:0001734	mRNA m(6)A methyltransferase activity	Catalysis of the reaction: an adenosine in mRNA + S-adenosyl-L-methionine = an N(6)-methyladenosine in mRNA + H+ + S-adenosyl-L-homocysteine. This activity is the methylation of adenines in mRNA with the consensus sequence RRACH, where R is a purine, and H is C, A, or U.

10 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0008174	GO:0001734
is_a	GO:0140098	GO:0001734
is_a	GO:0008173	GO:0001734
is_a	GO:0003824	GO:0001734
is_a	GO:0008168	GO:0001734
is_a	GO:0016740	GO:0001734
is_a	GO:0003674	GO:0001734
is_a	GO:0016741	GO:0001734
is_a	GO:0140640	GO:0001734
is_a	GO:0008757	GO:0001734

1 Synonyms

• Name: mRNA (N6-adenosine)-methyltransferase activity
• Type: synonym