WormMine: GOTerm GO:0003712 transcription coregulator activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

264 Ontology Annotations

7 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0005488	binding	The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0005515	protein binding	Binding to a protein.
GO:0140110	transcription regulator activity	A molecular function that controls the rate, timing and/or magnitude of gene transcription. The function of transcriptional regulators is to modulate gene expression at the transcription step so that they are expressed in the right cell at the right time and in the right amount throughout the life of the cell and the organism. Genes are transcriptional units, and include bacterial operons.
GO:0030674	protein-macromolecule adaptor activity	An adaptor activity that brings together two or more macromolecules in contact, permitting those molecules to function in a coordinated way. The adaptor can bring together two proteins, or a protein and another macromolecule such as a lipid or a nucleic acid.
GO:0060090	molecular adaptor activity	The binding activity of a molecule that brings together two or more molecules through a selective, non-covalent, often stoichiometric interaction, permitting those molecules to function in a coordinated way.
GO:0003712	transcription coregulator activity	A transcription regulator activity that modulates the transcription of specific gene sets via binding to a DNA-binding transcription factor at a specific genomic locus, either on its own or as part of a complex. Coregulators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators.

10 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0030674	GO:0003712
is_a	GO:0140110	GO:0003712
is_a	GO:0060090	GO:0003712
has part	GO:0005515	GO:0003712
is_a	GO:0003674	GO:0003712
has part	GO:0005488	GO:0003712
has part	GO:0003674	GO:0003712
is_a	GO:0003712	GO:0003713
is_a	GO:0003712	GO:0003714
is_a	GO:0003712	GO:0016989

7 Synonyms

• Name: nuclear receptor coreceptor activity
• Type: synonym

• Name: transcription cofactor activity
• Type: synonym

• Name: RNA polymerase II transcriptional cofactor activity
• Type: synonym

• Name: transcriptional co-regulator
• Type: synonym

• Name: transcription coreceptor activity
• Type: synonym

• Name: GO:0016455
• Type: alt_id

• Name: GO:0001104
• Type: alt_id