WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0003852 2-isopropylmalate synthase activity GO

Namespace  molecular_function Obsolete  false
Description  Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

6 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0016746 acyltransferase activity Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor).
GO:0046912 acyltransferase activity, acyl groups converted into alkyl on transfer Catalysis of the transfer of an acyl group from one compound (donor) to another (acceptor), with the acyl group being converted into alkyl on transfer.
GO:0003852 2-isopropylmalate synthase activity Catalysis of the reaction: 3-methyl-2-oxobutanoate + acetyl-CoA + H2O = (2S)-2-isopropylmalate + CoA + H+.

5 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0046912 GO:0003852
is_a GO:0003674 GO:0003852
is_a GO:0016740 GO:0003852
is_a GO:0016746 GO:0003852
is_a GO:0003824 GO:0003852

8 Synonyms

Name Type
isopropylmalate synthetase activity synonym
3-carboxy-3-hydroxy-4-methylpentanoate 3-methyl-2-oxobutanoate-lyase (CoA-acetylating) activity synonym
alpha-IPM synthetase activity synonym
acetyl-CoA:3-methyl-2-oxobutanoate C-acetyltransferase (thioester-hydrolysing, carboxymethyl-forming) synonym
alpha-isopropylmalate synthetase activity synonym
alpha-isopropylmalate synthase activity synonym
isopropylmalate synthase activity synonym
alpha-isopropylmalic synthetase activity synonym