WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0004146 dihydrofolate reductase activity GO

Namespace  molecular_function Obsolete  false
Description  Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

18 Ontology Annotations

Annotation Extension Qualifier
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6 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016491 oxidoreductase activity Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0016646 oxidoreductase activity, acting on the CH-NH group of donors, NAD or NADP as acceptor Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces NAD or NADP.
GO:0004146 dihydrofolate reductase activity Catalysis of the reaction: 5,6,7,8-tetrahydrofolate + NADP+ = 7,8-dihydrofolate + NADPH + H+.
GO:0016645 oxidoreductase activity, acting on the CH-NH group of donors Catalysis of an oxidation-reduction (redox) reaction in which a CH-NH group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.

5 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016646 GO:0004146
is_a GO:0003674 GO:0004146
is_a GO:0016645 GO:0004146
is_a GO:0016491 GO:0004146
is_a GO:0003824 GO:0004146

13 Synonyms

Name Type
7,8-dihydrofolate reductase activity synonym
5,6,7,8-tetrahydrofolate:NADP+ oxidoreductase activity synonym
dihydrofolate reductase:thymidylate synthase activity synonym
DHFR synonym
dihydrofolic reductase activity synonym
dihydrofolic acid reductase activity synonym
folic reductase activity synonym
folic acid reductase activity synonym
pteridine reductase:dihydrofolate reductase activity synonym
NADPH-dihydrofolate reductase activity synonym
thymidylate synthetase-dihydrofolate reductase activity synonym
tetrahydrofolate dehydrogenase activity synonym
dihydrofolate reduction synonym