WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0004222 metalloendopeptidase activity GO

Namespace  molecular_function Obsolete  false
Description  Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

1169 Ontology Annotations

Annotation Extension Qualifier
  enables
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8 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0140096 catalytic activity, acting on a protein Catalytic activity that acts to modify a protein.
GO:0008233 peptidase activity Catalysis of the hydrolysis of a peptide bond. A peptide bond is a covalent bond formed when the carbon atom from the carboxyl group of one amino acid shares electrons with the nitrogen atom from the amino group of a second amino acid.
GO:0004175 endopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain.
GO:0008237 metallopeptidase activity Catalysis of the hydrolysis of peptide bonds by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.
GO:0004222 metalloendopeptidase activity Catalysis of the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain by a mechanism in which water acts as a nucleophile, one or two metal ions hold the water molecule in place, and charged amino acid side chains are ligands for the metal ions.

18 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0004175 GO:0004222
is_a GO:0008237 GO:0004222
is_a GO:0003674 GO:0004222
is_a GO:0016787 GO:0004222
is_a GO:0008233 GO:0004222
is_a GO:0003824 GO:0004222
is_a GO:0140096 GO:0004222
negatively regulates GO:0004222 GO:0008191
is_a GO:0004222 GO:1902945
is_a GO:0004222 GO:1902945
regulates GO:0004222 GO:1904683
regulates GO:0004222 GO:1904683
negatively regulates GO:0004222 GO:1904684
negatively regulates GO:0004222 GO:1904684
regulates GO:0004222 GO:1904684
positively regulates GO:0004222 GO:1904685
positively regulates GO:0004222 GO:1904685
regulates GO:0004222 GO:1904685

2 Synonyms

Name Type
metalloendoproteinase activity synonym
metalloendoprotease activity synonym