WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity GO

Namespace  molecular_function Obsolete  false
Description  Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

86 Ontology Annotations

Annotation Extension Qualifier
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables
  enables

10 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0016788 hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond.
GO:0042578 phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
GO:0008081 phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
GO:0004629 phospholipase C activity Catalysis of the reaction: a phospholipid + H2O = 1,2-diacylglycerol + a phosphatidate.
GO:0004435 phosphatidylinositol-4,5-bisphosphate phospholipase C activity Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate) + H2O = 1D-myo-inositol 1,4,5-trisphosphate + a 1,2-diacyl-sn-glycerol + H+.
GO:0016298 lipase activity Catalysis of the hydrolysis of a lipid.
GO:0004620 phospholipase activity Catalysis of the hydrolysis of a glycerophospholipid.

9 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0004629 GO:0004435
is_a GO:0016298 GO:0004435
is_a GO:0008081 GO:0004435
is_a GO:0042578 GO:0004435
is_a GO:0003674 GO:0004435
is_a GO:0004620 GO:0004435
is_a GO:0016787 GO:0004435
is_a GO:0016788 GO:0004435
is_a GO:0003824 GO:0004435

10 Synonyms

Name Type
monophosphatidylinositol phosphodiesterase activity synonym
1-phosphatidyl-1D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity synonym
1-phosphatidylinositol-4,5-bisphosphate phosphodiesterase activity synonym
1-phosphatidyl-D-myo-inositol-4,5-bisphosphate inositoltrisphosphohydrolase activity synonym
phosphatidylinositol-4,5-bisphosphate hydrolysis synonym
phosphatidylinositol phospholipase C activity synonym
phosphoinositide phospholipase C activity synonym
phosphoinositidase C activity synonym
triphosphoinositide phosphodiesterase activity synonym
PI-PLC activity synonym