WormMine: GOTerm GO:0004491 methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

13 Ontology Annotations

6 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016491	oxidoreductase activity	Catalysis of an oxidation-reduction (redox) reaction, a reversible chemical reaction in which the oxidation state of an atom or atoms within a molecule is altered. One substrate acts as a hydrogen or electron donor and becomes oxidized, while the other acts as hydrogen or electron acceptor and becomes reduced.
GO:0016620	oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces NAD or NADP.
GO:0016903	oxidoreductase activity, acting on the aldehyde or oxo group of donors	Catalysis of an oxidation-reduction (redox) reaction in which an aldehyde or ketone (oxo) group acts as a hydrogen or electron donor and reduces a hydrogen or electron acceptor.
GO:0004491	methylmalonate-semialdehyde dehydrogenase (acylating, NAD) activity	Catalysis of the reaction: 2-methyl-3-oxopropanoate + CoA + NAD+ = propanoyl-CoA + CO2 + NADH + H+. Can also use malonate (3-oxopropanoate) as a substrate. The reaction occurs in two steps with the decarboxylation process preceding CoA-binding. Bicarbonate rather than CO2 is released as a final product.

5 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0016620	GO:0004491
is_a	GO:0016903	GO:0004491
is_a	GO:0016491	GO:0004491
is_a	GO:0003824	GO:0004491
is_a	GO:0003674	GO:0004491

3 Synonyms

• Name: methylmalonate-semialdehyde dehydrogenase (acylating) activity
• Type: synonym

• Name: MMSA dehydrogenase activity
• Type: synonym

• Name: MSDH activity
• Type: synonym