WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0004528 phosphodiesterase I activity GO

Namespace  molecular_function Obsolete  false
Description  Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

1 Ontology Annotations

Annotation Extension Qualifier
  enables

9 Parents

Identifier Name Description
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0004518 nuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0016788 hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond.
GO:0042578 phosphoric ester hydrolase activity Catalysis of the reaction: RPO-R' + H2O = RPOOH + R'H. This reaction is the hydrolysis of any phosphoric ester bond, any ester formed from orthophosphoric acid, O=P(OH)3.
GO:0004527 exonuclease activity Catalysis of the hydrolysis of ester linkages within nucleic acids by removing nucleotide residues from the 3' or 5' end.
GO:0008081 phosphoric diester hydrolase activity Catalysis of the hydrolysis of a phosphodiester to give a phosphomonoester and a free hydroxyl group.
GO:0004528 phosphodiesterase I activity Catalysis of the sequential hydrolytic removal of 5'-nucleotides from the 3'-hydroxy termini of 3'-hydroxy-terminated oligonucleotides.

10 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0008081 GO:0004528
is_a GO:0004527 GO:0004528
is_a GO:0004518 GO:0004528
is_a GO:0003824 GO:0004528
is_a GO:0042578 GO:0004528
is_a GO:0003674 GO:0004528
is_a GO:0016787 GO:0004528
is_a GO:0016788 GO:0004528
positively regulates GO:0004528 GO:1902800
positively regulates GO:0004528 GO:1902800

15 Synonyms

Name Type
5' nucleotide phosphodiesterase/alkaline phosphodiesterase I activity synonym
5'-exonuclease activity synonym
5'-NPDase activity synonym
5'-nucleotide phosphodiesterase activity synonym
5'-PDase activity synonym
5'-PDE activity synonym
5'-phosphodiesterase activity synonym
5'NPDE activity synonym
alkaline phosphodiesterase activity synonym
exonuclease I activity synonym
nucleotide pyrophosphatase/phosphodiesterase I activity synonym
oligonucleate 5'-nucleotidohydrolase activity synonym
orthophosphoric diester phosphohydrolase activity synonym
PDE I activity synonym
phosphodiesterase activity synonym