WormMine: GOTerm GO:0004623 phospholipase A2 activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

101 Ontology Annotations

8 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0016788	hydrolase activity, acting on ester bonds	Catalysis of the hydrolysis of any ester bond.
GO:0052689	carboxylic ester hydrolase activity	Catalysis of the hydrolysis of a carboxylic ester bond.
GO:0016298	lipase activity	Catalysis of the hydrolysis of a lipid.
GO:0004620	phospholipase activity	Catalysis of the hydrolysis of a glycerophospholipid.
GO:0004623	phospholipase A2 activity	Catalysis of the reaction: a 1,2-diacyl-sn-glycero-3-phospholipid + H2O = 1-acyl-sn-glycero-3-phospholipid + a fatty acid. This reaction removes the fatty acid attached to the sn2-position. Substrates include phosphatidylcholine, phosphatidylethanolamine, choline plasmalogen and phosphatides.

21 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0052689	GO:0004623
is_a	GO:0004620	GO:0004623
is_a	GO:0016298	GO:0004623
is_a	GO:0003674	GO:0004623
is_a	GO:0016787	GO:0004623
is_a	GO:0016788	GO:0004623
is_a	GO:0003824	GO:0004623
positively regulates	GO:0004623	GO:0016005
negatively regulates	GO:0004623	GO:0019834
regulates	GO:0004623	GO:0032429
regulates	GO:0004623	GO:0032429
positively regulates	GO:0004623	GO:0032430
positively regulates	GO:0004623	GO:0032430
regulates	GO:0004623	GO:0032430
positively regulates	GO:0004623	GO:0032431
regulates	GO:0004623	GO:0032431
is_a	GO:0004623	GO:0047498
is_a	GO:0004623	GO:0047499
negatively regulates	GO:0004623	GO:1900138
negatively regulates	GO:0004623	GO:1900138
regulates	GO:0004623	GO:1900138

10 Synonyms

• Name: cytosolic phospholipase A2 activity
• Type: synonym

• Name: lecithinase A activity
• Type: synonym

• Name: phosphatidase activity
• Type: synonym

• Name: phosphatidolipase activity
• Type: synonym

• Name: phosphatidylcholine 2-acylhydrolase activity
• Type: synonym

• Name: phospholipase A2 activity (consuming 1,2-dipalmitoylphosphatidylcholine)
• Type: synonym

• Name: phospholipase A2 activity consuming 1,2-dioleoylphosphatidylethanolamine)
• Type: synonym

• Name: secreted phospholipase A2 activity
• Type: synonym

• Name: GO:0102567
• Type: alt_id

• Name: GO:0102568
• Type: alt_id