WormMine: GOTerm GO:0004844 uracil DNA N-glycosylase activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

14 Ontology Annotations

10 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0140640	catalytic activity, acting on a nucleic acid	Catalytic activity that acts to modify a nucleic acid.
GO:0140097	catalytic activity, acting on DNA	Catalytic activity that acts to modify DNA.
GO:0016787	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0016798	hydrolase activity, acting on glycosyl bonds	Catalysis of the hydrolysis of any glycosyl bond.
GO:0019104	DNA N-glycosylase activity	Catalysis of the removal of damaged bases by cleaving the N-C1' glycosidic bond between the target damaged DNA base and the deoxyribose sugar. The reaction releases a free base and leaves an apurinic/apyrimidinic (AP) site.
GO:0016799	hydrolase activity, hydrolyzing N-glycosyl compounds	Catalysis of the hydrolysis of any N-glycosyl bond.
GO:0097506	deaminated base DNA N-glycosylase activity	DNA N-glycosylase activity acting on deaminated bases.
GO:0004844	uracil DNA N-glycosylase activity	Catalysis of the cleavage of the N-C1' glycosidic bond between the damaged DNA base and the deoxyribose sugar, releasing a free base and leaving an apyrimidinic (AP) site. Enzymes with this activity recognize and remove uracil bases in DNA that result from the deamination of cytosine or the misincorporation of dUTP opposite an adenine.

11 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:0097506	GO:0004844
is_a	GO:0140640	GO:0004844
is_a	GO:0019104	GO:0004844
is_a	GO:0140097	GO:0004844
is_a	GO:0016799	GO:0004844
is_a	GO:0003674	GO:0004844
is_a	GO:0016798	GO:0004844
is_a	GO:0016787	GO:0004844
is_a	GO:0003824	GO:0004844
is_a	GO:0004844	GO:0017065
is_a	GO:0004844	GO:0043739

1 Synonyms

• Name: uracil-DNA glycosylase activity
• Type: synonym