WormMine: GOTerm GO:0005085 guanyl-nucleotide exchange factor activity GO

• Namespace: molecular_function
• Obsolete: false
• Description: Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

593 Ontology Annotations

30 Parents

Identifier	Name	Description
GO:0003674	molecular_function	A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824	catalytic activity	Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016787	hydrolase activity	Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0036094	small molecule binding	Binding to a small molecule, any low molecular weight, monomeric, non-encoded molecule.
GO:0005488	binding	The selective, non-covalent, often stoichiometric, interaction of a molecule with one or more specific sites on another molecule.
GO:0016817	hydrolase activity, acting on acid anhydrides	Catalysis of the hydrolysis of any acid anhydride.
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	Catalysis of the hydrolysis of any acid anhydride which contains phosphorus.
GO:0016462	pyrophosphatase activity	Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups.
GO:0017111	ribonucleoside triphosphate phosphatase activity	Catalysis of the reaction: a ribonucleoside triphosphate + H2O = a ribonucleoside diphosphate + H+ + phosphate.
GO:1901363	heterocyclic compound binding	Binding to heterocyclic compound.
GO:1901265	nucleoside phosphate binding	Binding to nucleoside phosphate.
GO:0043167	ion binding	Binding to an ion, a charged atoms or groups of atoms.
GO:0043168	anion binding	Binding to an anion, a charged atom or group of atoms with a net negative charge.
GO:0005515	protein binding	Binding to a protein.
GO:0098772	molecular function regulator activity	A molecular function regulator regulates the activity of its target via non-covalent binding that does not result in covalent modification to the target. Examples of molecular function regulators include regulatory subunits of multimeric enzymes and channels. Mechanisms of regulation include allosteric changes in the target and competitive inhibition.
GO:0000166	nucleotide binding	Binding to a nucleotide, any compound consisting of a nucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose or deoxyribose.
GO:0035639	purine ribonucleoside triphosphate binding	Binding to a purine ribonucleoside triphosphate, a compound consisting of a purine base linked to a ribose sugar esterified with triphosphate on the sugar.
GO:0097367	carbohydrate derivative binding	Binding to a carbohydrate derivative.
GO:0017076	purine nucleotide binding	Binding to a purine nucleotide, a compound consisting of a purine nucleoside esterified with (ortho)phosphate.
GO:0032553	ribonucleotide binding	Binding to a ribonucleotide, any compound consisting of a ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
GO:0032555	purine ribonucleotide binding	Binding to a purine ribonucleotide, any compound consisting of a purine ribonucleoside that is esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
GO:0030234	enzyme regulator activity	Binds to and modulates the activity of an enzyme.
GO:0003924	GTPase activity	Catalysis of the reaction: GTP + H2O = GDP + H+ + phosphate.
GO:0019001	guanyl nucleotide binding	Binding to a guanyl nucleotide, consisting of guanosine esterified with (ortho)phosphate.
GO:0032561	guanyl ribonucleotide binding	Binding to a guanyl ribonucleotide, any compound consisting of guanosine esterified with (ortho)phosphate or an oligophosphate at any hydroxyl group on the ribose moiety.
GO:0005525	GTP binding	Binding to GTP, guanosine triphosphate.
GO:0005085	guanyl-nucleotide exchange factor activity	Stimulates the exchange of GDP to GTP on a signaling GTPase, changing its conformation to its active form. Guanine nucleotide exchange factors (GEFs) act by stimulating the release of guanosine diphosphate (GDP) to allow binding of guanosine triphosphate (GTP), which is more abundant in the cell under normal cellular physiological conditions.
GO:0030695	GTPase regulator activity	Binds to and modulates the activity of a GTPase.
GO:0019003	GDP binding	Binding to GDP, guanosine 5'-diphosphate.
GO:0060589	nucleoside-triphosphatase regulator activity	Binds to and modulates the activity of an NTPase.

60 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
positively regulates	GO:0005525	GO:0005085
is_a	GO:0030695	GO:0005085
negatively regulates	GO:0019003	GO:0005085
positively regulates	GO:0097367	GO:0005085
negatively regulates	GO:0032561	GO:0005085
positively regulates	GO:0036094	GO:0005085
positively regulates	GO:0035639	GO:0005085
has part	GO:0003674	GO:0005085
positively regulates	GO:0005488	GO:0005085
regulates	GO:0016787	GO:0005085
positively regulates	GO:0043168	GO:0005085
is_a	GO:0030234	GO:0005085
positively regulates	GO:0043167	GO:0005085
positively regulates	GO:1901265	GO:0005085
regulates	GO:0003924	GO:0005085
positively regulates	GO:1901363	GO:0005085
has part	GO:0005515	GO:0005085
negatively regulates	GO:0017076	GO:0005085
is_a	GO:0098772	GO:0005085
regulates	GO:0003824	GO:0005085
negatively regulates	GO:0036094	GO:0005085
positively regulates	GO:0019001	GO:0005085
positively regulates	GO:0032561	GO:0005085
is_a	GO:0060589	GO:0005085
negatively regulates	GO:0000166	GO:0005085
negatively regulates	GO:0003674	GO:0005085
regulates	GO:0016818	GO:0005085
negatively regulates	GO:0032553	GO:0005085
positively regulates	GO:0000166	GO:0005085
regulates	GO:0016817	GO:0005085

32 Synonyms

• Name: ARF guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: cAMP-dependent guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: GDP-dissociation stimulator activity
• Type: synonym

• Name: GDS
• Type: synonym

• Name: GEF
• Type: synonym

• Name: GNRP
• Type: synonym

• Name: guanyl-nucleotide release factor activity
• Type: synonym

• Name: guanyl-nucleotide releasing factor
• Type: synonym

• Name: Rab guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: Rac guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: Ral guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: Ran guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: Rap guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: Ras guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: Rho guanine nucleotide exchange factor
• Type: synonym

• Name: Rho guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: RhoGEF
• Type: synonym

• Name: Sar guanyl-nucleotide exchange factor activity
• Type: synonym

• Name: GO:0005086
• Type: alt_id

• Name: GO:0005087
• Type: alt_id

• Name: GO:0005088
• Type: alt_id

• Name: GO:0005089
• Type: alt_id

• Name: GO:0005090
• Type: alt_id

• Name: GO:0008321
• Type: alt_id

• Name: GO:0008433
• Type: alt_id

• Name: GO:0016219
• Type: alt_id

• Name: GO:0016220
• Type: alt_id

• Name: GO:0017034
• Type: alt_id

• Name: GO:0017112
• Type: alt_id

• Name: GO:0017132
• Type: alt_id