WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0005943 phosphatidylinositol 3-kinase complex, class IA GO

Namespace  cellular_component Obsolete  false
Description  A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

1 Ontology Annotations

Annotation Extension Qualifier
  part_of

12 Parents

Identifier Name Description
GO:1902494 catalytic complex A protein complex which is capable of catalytic activity.
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:1990234 transferase complex A protein complex capable of catalyzing the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor).
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0061695 transferase complex, transferring phosphorus-containing groups A transferase complex capable of catalysis of the transfer of a phosphorus-containing group from one compound (donor) to another (acceptor).
GO:0019898 extrinsic component of membrane The component of a membrane consisting of gene products and protein complexes that are loosely bound to one of its surfaces, but not integrated into the hydrophobic region.
GO:0005942 phosphatidylinositol 3-kinase complex A protein complex capable of phosphatidylinositol 3-kinase activity and containing subunits of any phosphatidylinositol 3-kinase (PI3K) enzyme. These complexes are divided in three classes (called I, II and III) that differ for their presence across taxonomic groups and for the type of their constituents. Catalytic subunits of phosphatidylinositol 3-kinase enzymes are present in all 3 classes; regulatory subunits of phosphatidylinositol 3-kinase enzymes are present in classes I and III; adaptor proteins have been observed in class II complexes and may be present in other classes too.
GO:0097651 phosphatidylinositol 3-kinase complex, class I A phosphatidylinositol 3-kinase complex that contains a catalytic and a regulatory subunit of a phosphatidylinositol 3-kinase (PI3K) enzyme, plus one or more adaptor proteins. Class I PI3Ks phosphorylate phosphatidylinositol [PI], phosphatidylinositol-4-phosphate [PI(4)P] and phosphatidylinositol-4,5-bisphosphate [PI(4,5)P2], and are divided into subclasses A and B according to the type of adaptor subunit with which they associate. The class I PI3K subfamily of genes comprises members in vertebrates, worm and fly, but none in yeast.
GO:0005943 phosphatidylinositol 3-kinase complex, class IA A class I phosphatidylinositol 3-kinase complex that possesses 1-phosphatidylinositol-4-phosphate 3-kinase activity; comprises a catalytic class IA phosphoinositide 3-kinase (PI3K) subunit and an associated SH2 domain-containing regulatory subunit that is a member of a family of related proteins often called p85 proteins. Through the interaction with the SH2-containing adaptor subunits, Class IA PI3K catalytic subunits are linked to tyrosine kinase signaling pathways.

12 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0097651 GO:0005943
part of GO:0005575 GO:0005943
part of GO:0019898 GO:0005943
is_a GO:0005575 GO:0005943
part of GO:0110165 GO:0005943
is_a GO:0032991 GO:0005943
part of GO:0016020 GO:0005943
is_a GO:0098796 GO:0005943
is_a GO:1902494 GO:0005943
is_a GO:0061695 GO:0005943
is_a GO:1990234 GO:0005943
is_a GO:0005942 GO:0005943

5 Synonyms

Name Type
1-phosphatidylinositol-4-phosphate 3-kinase, class IA complex synonym
class IA PI3K complex synonym
1-phosphatidylinositol-4-phosphate kinase, class IA complex synonym
GO:0035030 alt_id
phosphoinositide 3-kinase complex, class IA synonym