WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0006540 gamma-aminobutyrate shunt GO

Namespace  biological_process Obsolete  false
Description  The chemical reactions and pathways resulting in the formation of succinate from glutamate. Also known as GABA (gamma-aminobutyrate) shunt since it channels glutamate into the TCA cycle bypassing two steps of that cycle. There are three enzymes involved in the GABA shunt: glutamate decarboxylase (GAD), GABA aminotransferase (GABA-TA), and succinate semialdehyde dehydrogenase (SSADH). These three enzymes acting in concert to convert glutamate into succinate. The GABA shunt is predominantly associated with neurotransmission in the mammalian brain. It is also present in nonneuronal cells, in plants, in unicellular eukaryotes, and in prokaryotes.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

38 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0016740 transferase activity Catalysis of the transfer of a group, e.g. a methyl group, glycosyl group, acyl group, phosphorus-containing, or other groups, from one compound (generally regarded as the donor) to another compound (generally regarded as the acceptor). Transferase is the systematic name for any enzyme of EC class 2.
GO:0044238 primary metabolic process The chemical reactions and pathways involving those compounds which are formed as a part of the normal anabolic and catabolic processes. These processes take place in most, if not all, cells of the organism.
GO:0008152 metabolic process A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
GO:0009056 catabolic process A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0043436 oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
GO:0044281 small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:1901605 alpha-amino acid metabolic process The chemical reactions and pathways involving an alpha-amino acid.
GO:0006520 amino acid metabolic process The chemical reactions and pathways involving amino acids, carboxylic acids containing one or more amino groups.
GO:0170033 L-amino acid metabolic process The chemical reactions and pathways involving an L-amino acid.
GO:0046395 carboxylic acid catabolic process The chemical reactions and pathways resulting in the breakdown of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
GO:0044282 small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0016054 organic acid catabolic process The chemical reactions and pathways resulting in the breakdown of organic acids, any acidic compound containing carbon in covalent linkage.
GO:0170039 proteinogenic amino acid metabolic process The chemical reactions and pathways involving any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
GO:0009064 glutamine family amino acid metabolic process The chemical reactions and pathways involving amino acids of the glutamine family, comprising arginine, glutamate, glutamine and proline.
GO:0009063 amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of amino acids, organic acids containing one or more amino substituents.
GO:0170035 L-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of an L-amino acid.
GO:1901606 alpha-amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of an alpha-amino acid.
GO:0170040 proteinogenic amino acid catabolic process The chemical reactions and pathways resulting in the breakdown of any amino acid that is incorporated into protein naturally by ribosomal translation of mRNA, and that has a specific codon for translation from mRNA to protein.
GO:0016831 carboxy-lyase activity Catalysis of the nonhydrolytic addition or removal of a carboxyl group to or from a compound.
GO:0016830 carbon-carbon lyase activity Catalysis of the cleavage of C-C bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond.
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016769 transferase activity, transferring nitrogenous groups Catalysis of the transfer of a nitrogenous group from one compound (donor) to another (acceptor).
GO:0008483 transaminase activity Catalysis of the transfer of an amino group to an acceptor, usually a 2-oxo acid.
GO:0004351 glutamate decarboxylase activity Catalysis of the reaction: L-glutamate = 4-aminobutanoate + CO2.

37 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
has part GO:0004351 GO:0006540
is_a GO:0006105 GO:0006540
is_a GO:0006538 GO:0006540
has part GO:0034386 GO:0006540
is_a GO:0009064 GO:0006540
is_a GO:0009065 GO:0006540
is_a GO:0008152 GO:0006540
has part GO:0016831 GO:0006540
is_a GO:0009063 GO:0006540
is_a GO:0008150 GO:0006540
is_a GO:0016054 GO:0006540
has part GO:0003824 GO:0006540
is_a GO:1901605 GO:0006540
is_a GO:1901606 GO:0006540
is_a GO:0044281 GO:0006540
is_a GO:0044282 GO:0006540
is_a GO:0170040 GO:0006540
is_a GO:0006520 GO:0006540
has part GO:0016830 GO:0006540
is_a GO:0043436 GO:0006540
has part GO:0016769 GO:0006540
is_a GO:0009056 GO:0006540
is_a GO:0170039 GO:0006540
is_a GO:0043648 GO:0006540
is_a GO:0006082 GO:0006540
is_a GO:0043649 GO:0006540
has part GO:0003674 GO:0006540
has part GO:0016829 GO:0006540
has part GO:0008483 GO:0006540
is_a GO:0019752 GO:0006540

7 Synonyms

Name Type
gamma aminobutyrate shunt synonym
glutamate decarboxylation to succinate synonym
degradation of glutamate to succinate through GABA synonym
GABA shunt synonym
glutamate degradation via 4-aminobutyrate synonym
glutamate degradation via GABA synonym
4-aminobutyrate shunt synonym