WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0008841 dihydrofolate synthase activity GO

Namespace  molecular_function Obsolete  false
Description  Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

27 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
GO:0009058 biosynthetic process A cellular process consisting of the biochemical pathways by which a living organism synthesizes chemical substances. This typically represents the energy-requiring part of metabolism in which simpler substances are transformed into more complex ones.
GO:0046394 carboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of carboxylic acids, any organic acid containing one or more carboxyl (-COOH) groups.
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0043436 oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
GO:0044281 small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0044283 small molecule biosynthetic process The chemical reactions and pathways resulting in the formation of small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0016053 organic acid biosynthetic process The chemical reactions and pathways resulting in the formation of organic acids, any acidic compound containing carbon in covalent linkage.
GO:0016874 ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
GO:0006575 modified amino acid metabolic process The chemical reactions and pathways involving compounds derived from amino acids, organic acids containing one or more amino substituents.
GO:0016879 ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0016881 acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0042398 modified amino acid biosynthetic process The chemical reactions and pathways resulting in the formation of compounds derived from amino acids, organic acids containing one or more amino substituents.
GO:0009396 folic acid-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of folic acid and its derivatives.
GO:0042558 pteridine-containing compound metabolic process The chemical reactions and pathways involving any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.
GO:0042559 pteridine-containing compound biosynthetic process The chemical reactions and pathways resulting in the formation of any compound containing pteridine (pyrazino(2,3-dipyrimidine)), e.g. pteroic acid, xanthopterin and folic acid.
GO:0006760 folic acid-containing compound metabolic process The chemical reactions and pathways involving a folic acid-containing compound, i.e. any of a group of heterocyclic compounds based on the pteroic acid skeleton conjugated with one or more L-glutamic acid or L-glutamate units.
GO:0043648 dicarboxylic acid metabolic process The chemical reactions and pathways involving dicarboxylic acids, any organic acid containing two carboxyl (COOH) groups or anions (COO-).
GO:0043650 dicarboxylic acid biosynthetic process The chemical reactions and pathways resulting in the formation of dicarboxylic acids, any organic acid containing two carboxyl (-COOH) groups.
GO:0006761 dihydrofolate biosynthetic process The chemical reactions and pathways resulting in the formation of dihydrofolate, the dihydroxylated derivative of folate.
GO:0046452 dihydrofolate metabolic process The chemical reactions and pathways involving dihydrofolate, the dihydroxylated derivative of folate.
GO:0008841 dihydrofolate synthase activity Catalysis of the reaction: ATP + dihydropterate + L-glutamate = ADP + phosphate + dihydrofolate.

26 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0016881 GO:0008841
part of GO:0006761 GO:0008841
part of GO:0044283 GO:0008841
part of GO:0046452 GO:0008841
is_a GO:0016879 GO:0008841
part of GO:0046394 GO:0008841
is_a GO:0016874 GO:0008841
part of GO:0016053 GO:0008841
part of GO:0043650 GO:0008841
part of GO:0019752 GO:0008841
is_a GO:0003824 GO:0008841
part of GO:0044281 GO:0008841
part of GO:0009396 GO:0008841
part of GO:0008152 GO:0008841
part of GO:0006082 GO:0008841
part of GO:0008150 GO:0008841
part of GO:0006760 GO:0008841
part of GO:0009058 GO:0008841
is_a GO:0003674 GO:0008841
part of GO:0042398 GO:0008841
part of GO:0009987 GO:0008841
part of GO:0006575 GO:0008841
part of GO:0043436 GO:0008841
part of GO:0042558 GO:0008841
part of GO:0043648 GO:0008841
part of GO:0042559 GO:0008841

12 Synonyms

Name Type
7,8-dihydropteroate:L-glutamate ligase (ADP) activity synonym
7,8-dihydropteroate:L-glutamate ligase (ADP-forming) synonym
DHFS activity synonym
dihydrofolate synthetase activity synonym
dihydrofolate synthetase-folylpolyglutamate synthetase activity synonym
dihydropteroate:L-glutamate ligase (ADP-forming) activity synonym
FHFS activity synonym
FHFS/FPGS activity synonym
folylpoly-(gamma-glutamate) synthetase-dihydrofolate synthase activity synonym
H(2)-folate synthetase activity synonym
H2-folate synthetase activity synonym
7,8-dihydrofolate synthetase activity synonym