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Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione GO
Namespace  biological_process Obsolete  false
Description  The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.
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0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

12 Ontology Annotations

Annotation Extension Qualifier
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28 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0008152 metabolic process A cellular process consisting of the biochemical pathways by which a living organism transforms chemical substances. This includes including anabolism (biosynthetic process) and catabolism (catabolic process). Metabolic processes includes the transformation of small molecules, as well macromolecular processes such as DNA repair and replication, protein synthesis and degradation.
GO:0016787 hydrolase activity Catalysis of the hydrolysis of various bonds, e.g. C-O, C-N, C-C, phosphoric anhydride bonds, etc.
GO:0016788 hydrolase activity, acting on ester bonds Catalysis of the hydrolysis of any ester bond.
GO:0009056 catabolic process A cellular process consisting of the biochemical pathways by which a living organism breaks down substances. This includes the breakdown of carbon compounds with the liberation of energy for use by the cell or organism.
GO:0032787 monocarboxylic acid metabolic process The chemical reactions and pathways involving monocarboxylic acids, any organic acid containing one carboxyl (COOH) group or anion (COO-).
GO:0019752 carboxylic acid metabolic process The chemical reactions and pathways involving carboxylic acids, any organic acid containing one or more carboxyl (COOH) groups or anions (COO-).
GO:0043436 oxoacid metabolic process The chemical reactions and pathways involving any oxoacid; an oxoacid is a compound which contains oxygen, at least one other element, and at least one hydrogen bound to oxygen, and which produces a conjugate base by loss of positive hydrogen ion(s) (hydrons).
GO:0006082 organic acid metabolic process The chemical reactions and pathways involving organic acids, any acidic compound containing carbon in covalent linkage.
GO:0044281 small molecule metabolic process The chemical reactions and pathways involving small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0044282 small molecule catabolic process The chemical reactions and pathways resulting in the breakdown of small molecules, any low molecular weight, monomeric, non-encoded molecule.
GO:0016829 lyase activity Catalysis of the cleavage of C-C, C-O, C-N and other bonds by other means than by hydrolysis or oxidation, or conversely adding a group to a double bond. They differ from other enzymes in that two substrates are involved in one reaction direction, but only one in the other direction. When acting on the single substrate, a molecule is eliminated and this generates either a new double bond or a new ring.
GO:0016790 thiolester hydrolase activity Catalysis of the reaction: RCO-SR' + H2O = RCOOH + HSR'. This reaction is the hydrolysis of a thiolester bond, an ester formed from a carboxylic acid and a thiol (i.e., RCO-SR'), such as that found in acetyl-coenzyme A.
GO:0016846 carbon-sulfur lyase activity Catalysis of the elimination of hydrogen sulfide or substituted H2S.
GO:0004416 hydroxyacylglutathione hydrolase activity Catalysis of the reaction: (S)-(2-hydroxyacyl)glutathione + H2O = glutathione + a 2-hydroxy carboxylate.
GO:0004462 lactoylglutathione lyase activity Catalysis of the reaction: (R)-S-lactoylglutathione = glutathione + methylglyoxal.
GO:0006081 aldehyde metabolic process The chemical reactions and pathways involving aldehydes, any organic compound with the formula R-CH=O, as carried out by individual cells.
GO:0006089 lactate metabolic process The chemical reactions and pathways involving lactate, the anion of lactic acid.
GO:0042180 ketone metabolic process The chemical reactions and pathways involving any of a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms, as carried out by individual cells. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
GO:0042182 ketone catabolic process The chemical reactions and pathways resulting in the breakdown of ketones, a class of organic compounds that contain the carbonyl group, CO, and in which the carbonyl group is bonded only to carbon atoms. The general formula for a ketone is RCOR, where R and R are alkyl or aryl groups.
GO:0046185 aldehyde catabolic process The chemical reactions and pathways resulting in the breakdown of aldehydes, any organic compound with the formula R-CH=O.
GO:0009438 methylglyoxal metabolic process The chemical reactions and pathways involving methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
GO:0061727 methylglyoxal catabolic process to lactate The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into lactate.
GO:0051596 methylglyoxal catabolic process The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, the aldehyde of pyruvic acid.
GO:0019243 methylglyoxal catabolic process to D-lactate via S-lactoyl-glutathione The chemical reactions and pathways resulting in the breakdown of methylglyoxal, CH3-CO-CHO, into D-lactate via the intermediate S-lactoyl-glutathione. Glutathione is used in the first step of the pathway and then regenerated in the second step.

27 Relations

Relationship
Parent Term . Identifier
Child Term . Identifier
has part GO:0004462 GO:0019243
has part GO:0004416 GO:0019243
is_a GO:0061727 GO:0019243
has part GO:0003824 GO:0019243
is_a GO:0042182 GO:0019243
has part GO:0016790 GO:0019243
is_a GO:0042180 GO:0019243
is_a GO:0044281 GO:0019243
is_a GO:0046185 GO:0019243
is_a GO:0044282 GO:0019243
is_a GO:0009438 GO:0019243
has part GO:0016788 GO:0019243
is_a GO:0009987 GO:0019243
has part GO:0016787 GO:0019243
is_a GO:0006089 GO:0019243
is_a GO:0043436 GO:0019243
is_a GO:0009056 GO:0019243
has part GO:0016829 GO:0019243
is_a GO:0008150 GO:0019243
is_a GO:0006081 GO:0019243
is_a GO:0006082 GO:0019243
is_a GO:0008152 GO:0019243
has part GO:0016846 GO:0019243
has part GO:0003674 GO:0019243
is_a GO:0032787 GO:0019243
is_a GO:0051596 GO:0019243
is_a GO:0019752 GO:0019243

7 Synonyms

Name Type
D-lactate biosynthesis from methylglyoxal synonym
D-lactate biosynthetic process from methylglyoxal synonym
glyoxalase system synonym
methylglyoxal breakdown to D-lactate synonym
methylglyoxal catabolism to D-lactate via S-lactoyl-glutathione synonym
methylglyoxal degradation to D-lactate synonym
methylglyoxal detoxification synonym