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WBPhenotype:0000463
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metabolic pathway variant
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Animals exhibit variations in processes that are responsible for chemical changes compared to control animals. Metabolic processes typically transform small molecules, but also include macromolecular processes such as DNA repair and replication, and protein synthesis and degradation. |
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WBPhenotype:0000727
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enzyme activity variant
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Any variation in the function of naturally occurring macromolecular substances known as enzymes compared to control. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein (can include an RNA component). |
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WBPhenotype:0001574
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ATP levels variant
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Animals exhibit variations in the cellular levels of Adenosine-5'-triphosphate (ATP), compared to control. ATP is a nucleotide that plays a versatile role in cell biology. |
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WBPhenotype:0000508
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nonsense mRNA accumulation
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Animals exhibit a decrease in the regulated breakdown of mRNA transcripts in which an amino-acid codon has changed to a premature stop codon and the 3 prime end is not protected by a poly(A) tail. |
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WBPhenotype:0000507
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acetylcholine levels variant
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Animals exhibit variations in the amount of acetylcholine compared to control animals at a defined stage. Acetylcholine is the acetic acid ester of the organic base choline. |
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WBPhenotype:0002381
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pheromone production variant
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Animals exhibit variations in the amount and/or quality of pheromone produced compared to control animals at a defined stage. |
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WBPhenotype:0001369
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protein interaction variant
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Variations in the selective and non-covalent physical association between two or more proteins, or a protein and nucleic acid/macromolecular complex, compared to control. |
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WBPhenotype:0000552
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GABA levels variant
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Animals exhibit variations in the amount of GABA compared to control animals at a defined stage. |
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WBPhenotype:0000725
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lipid metabolism variant
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Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of lipid within the organism or cell compared to control. |
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WBPhenotype:0001518
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biogenic amine physiology variant
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Any variation in the levels and/or localization of biogenic amines compared to control animals. |
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WBPhenotype:0002072
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carbohydrate metabolism variant
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Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of an internal store of carbohydrates within the organism or cell compared to control. |
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WBPhenotype:0000221
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neurotransmitter metabolism variant
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Animals exhibit variations in any chemical reaction or pathway involving neurotransmitters compared to control animals. Neurotransmitters are any of a group of substances that are released on excitation from the axon terminal of a presynaptic neuron of the central or peripheral nervous system and travel across the synaptic cleft to either excite or inhibit the target cell. |
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WBPhenotype:0001835
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energy expenditure variant
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Variations in the amount of energy consumed by an organism compared to control. Energy expenditure is often determined by assaying oxygen consumption. |
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WBPhenotype:0000122
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post translational processing variant
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Any variation in the posttranslational modification of a protein (which may include cleavage of peptide bonds) leading to the attainment of the full functional capacity of the protein compared to control. |
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WBPhenotype:0001843
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hormone metabolism variant
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Animals exhibit variations in any process that involves the degradation, biosynthesis or accumulation of hormones within the organism compared to control. Hormones are naturally occurring substances secreted by specialized cells that affect the metabolism or behavior of other cells possessing functional receptors for the hormone. |
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WBPhenotype:0002400
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glucose intolerant
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Animals do not live or live poorly in the presence of glucose concentrations that normally do not have an effect on control animals. |
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WBPhenotype:0002205
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hypersensitive to galactose
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Animals exhibit negative effects on growth, development, or metabolism when exposed to a galactose-rich diet, compared to control animals. |
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WBPhenotype:0002206
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galactose metabolism variant
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Animals process dietary galactose differently than control animals, these differences can result in increased and or decreased levels of intermediary galactose metabolites. |
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WBPhenotype:0001892
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glycogen levels variant
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Any variation in the levels of the polymerized form of glucose throughout the body of the animal as compared to controls. |
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WBPhenotype:0001757
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neuropeptide metabolism variant
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Animals exhibit variations in any process that involves the maintenance, biosynthesis or accumulation of signalling peptides in the organism compared to control. |
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WBPhenotype:0002525
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diet response variant
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Animals exhibit variations in their response to diet, compared to controls. |
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WBPhenotype:0001899
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glutathione levels variant
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Animals exhibit variations in the amount of glutathione compared to control animals at a defined stage. Glutathione, the tripeptide glutamylcysteinylglycine, acts as a coenzyme for some enzymes and as an antioxidant in the protection of sulfhydryl groups in enzymes and other proteins. |
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WBPhenotype:0002480
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heme levels variant
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Animals exhibit variations in the amount of heme compared to control animals. Heme is any compound of iron complexed in a porphyrin (tetrapyrrole) ring. |
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WBPhenotype:0002008
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glycation variant
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Animals exhibit variations in the non-enzymatic glycosylation process of attaching a protein or lipid to a sugar molecule, compared to control animals. |
