WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0021776 smoothened signaling pathway involved in spinal cord motor neuron cell fate specification GO

Namespace  biological_process Obsolete  false
Description  The series of molecular signals initiated by binding of a ligand to the transmembrane receptor smoothened in a precursor cell in the spinal cord that contributes to the process of a precursor cell becoming capable of differentiating autonomously into a motor neuron in an environment that is neutral with respect to the developmental pathway.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

41 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0023052 signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0007275 multicellular organism development The biological process whose specific outcome is the progression of a multicellular organism over time from an initial condition (e.g. a zygote or a young adult) to a later condition (e.g. a multicellular animal or an aged adult).
GO:0007389 pattern specification process Any developmental process that results in the creation of defined areas or spaces within an organism to which cells respond and eventually are instructed to differentiate.
GO:0032501 multicellular organismal process Any biological process, occurring at the level of a multicellular organism, pertinent to its function.
GO:0032502 developmental process A biological process whose specific outcome is the progression of an integrated living unit: an anatomical structure (which may be a subcellular structure, cell, tissue, or organ), or organism over time from an initial condition to a later condition.
GO:0048856 anatomical structure development The biological process whose specific outcome is the progression of an anatomical structure from an initial condition to its mature state. This process begins with the formation of the structure and ends with the mature structure, whatever form that may be including its natural destruction. An anatomical structure is any biological entity that occupies space and is distinguished from its surroundings. Anatomical structures can be macroscopic such as a carpel, or microscopic such as an acrosome.
GO:0048731 system development The process whose specific outcome is the progression of an organismal system over time, from its formation to the mature structure. A system is a regularly interacting or interdependent group of organs or tissues that work together to carry out a given biological process.
GO:0048869 cellular developmental process A biological process whose specific outcome is the progression of a cell over time from an initial condition to a later condition.
GO:0030154 cell differentiation The cellular developmental process in which a relatively unspecialized cell, e.g. embryonic or regenerative cell, acquires specialized structural and/or functional features that characterize a specific cell. Differentiation includes the processes involved in commitment of a cell to a specific fate and its subsequent development to the mature state.
GO:0007166 cell surface receptor signaling pathway The series of molecular signals initiated by an extracellular ligand binding to a receptor located on the cell surface. The pathway ends with regulation of a downstream cellular process, e.g. transcription.
GO:0045165 cell fate commitment The cellular developmental process by which a cell establishes the intrinsic character of a cell or tissue region irreversibly committing it to a particular fate.
GO:0001708 cell fate specification The cellular developmental process involved in cell fate commitment in which the cell is designated to follow a developmental path, unless they receive extrinsic cues that direct an alternative fate.
GO:0048699 generation of neurons The process in which nerve cells are generated. This includes the production of neuroblasts and their differentiation into neurons.
GO:0030182 neuron differentiation The process in which a relatively unspecialized cell acquires specialized features of a neuron.
GO:0007399 nervous system development The process whose specific outcome is the progression of nervous tissue over time, from its formation to its mature state.
GO:0022008 neurogenesis Generation of cells within the nervous system.
GO:0048663 neuron fate commitment The process in which the developmental fate of a cell becomes restricted such that it will develop into a neuron.
GO:0003002 regionalization The pattern specification process that results in the subdivision of an axis or axes in space to define an area or volume in which specific patterns of cell differentiation will take place or in which cells interpret a specific environment.
GO:0007417 central nervous system development The process whose specific outcome is the progression of the central nervous system over time, from its formation to the mature structure. The central nervous system is the core nervous system that serves an integrating and coordinating function. In vertebrates it consists of the brain and spinal cord. In those invertebrates with a central nervous system it typically consists of a brain, cerebral ganglia and a nerve cord.
GO:0007224 smoothened signaling pathway The series of molecular signals generated as a consequence of activation of the transmembrane protein Smoothened.
GO:0009953 dorsal/ventral pattern formation The regionalization process in which the areas along the dorsal/ventral axis are established that will lead to differences in cell differentiation. The dorsal/ventral axis is defined by a line that runs orthogonal to both the anterior/posterior and left/right axes. The dorsal end is defined by the upper or back side of an organism. The ventral end is defined by the lower or front side of an organism.

48 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0021520 GO:0021776
is_a GO:0007224 GO:0021776
is_a GO:0021910 GO:0021776
part of GO:0021520 GO:0021776
is_a GO:0050794 GO:0021776
part of GO:0008150 GO:0021776
part of GO:0065007 GO:0021776
part of GO:0030182 GO:0021776
is_a GO:0007224 GO:0021776
part of GO:0051716 GO:0021776
is_a GO:0009987 GO:0021776
part of GO:0032502 GO:0021776
part of GO:0050789 GO:0021776
part of GO:0032501 GO:0021776
part of GO:0048663 GO:0021776
part of GO:0007417 GO:0021776
part of GO:0048665 GO:0021776
regulates GO:0009987 GO:0021776
part of GO:0009953 GO:0021776
part of GO:0021522 GO:0021776
part of GO:0048869 GO:0021776
part of GO:0007399 GO:0021776
is_a GO:0007166 GO:0021776
is_a GO:0050789 GO:0021776
is_a GO:0007165 GO:0021776
regulates GO:0008150 GO:0021776
is_a GO:0008150 GO:0021776
part of GO:0007154 GO:0021776
part of GO:0007275 GO:0021776
part of GO:0021515 GO:0021776

3 Synonyms

Name Type
smoothened signalling pathway involved in spinal cord motor neuron cell fate specification synonym
hh signaling pathway involved in spinal cord motor neuron cell fate specification synonym
hedgehog signaling pathway involved in spinal cord motor neuron cell fate specification synonym