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WBPhenotype:0001645
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protein degradation variant
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Variations in the chemical reactions and pathways resulting in the directed breakdown of a protein (via the destruction of its native, active configuration) compared to control. |
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WBPhenotype:0001864
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protein transport variant
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Any variation in the processes that modulate the frequency, rate or extent of the directed movement of a protein into, out of, within or between cells by means of some external agent such as a transporter or pore compared to control. |
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WBPhenotype:0001719
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unfolded protein response variant
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Animals exhibit variations in any of the series of molecular signals generated as a consequence of the presence of unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria, compared to control. One such response is the increase in expression of chaperones. |
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WBPhenotype:0000121
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translation variant
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Variations in the chemical reactions and pathways resulting in the formation of a protein, compared to control. |
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WBPhenotype:0001806
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protein stabilization variant
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Any variation in the ability of a protein to resist disintegration via chemical or physical modifications compared to control. |
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WBPhenotype:0001382
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protein modification variant
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Variations in the covalent alteration of one or more amino acids occurring in proteins, peptides and nascent polypeptides (co-translational, post-translational modifications), compared to control. This includes the modification of charged tRNAs that are destined to occur in a protein (pre-translation modification). |
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WBPhenotype:0002010
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protein turnover variant
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The dynamics of the replacement of old proteins by newly synthesized or modified proteins varies from that of control animals. This phenotype is often measured by fluorescence recovery after photobleaching (FRAP). |
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WBPhenotype:0002009
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proteasome core activity variant
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Animals exhibit variations from controls in their protein degradation machinery, which functions through the hydrolysis of internal, alpha-peptide bonds in a polypeptide chain. |
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WBPhenotype:0001486
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unfolded protein accumulation
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Animals accumulate unfolded proteins in the endoplasmic reticulum (ER) and or the mitochondria. |
