WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0030122 AP-2 adaptor complex GO

Namespace  cellular_component Obsolete  false
Description  A heterotetrameric AP-type membrane coat adaptor complex that consists of alpha, beta2, mu2 and sigma2 subunits, and links clathrin to the membrane surface of a vesicle, and the cargo receptors during receptor/clathrin mediated endocytosis. Vesicles with AP-2-containing coats are normally found primarily near the plasma membrane, on endocytic vesicles. In at least humans, the AP-2 complex can be heterogeneric due to the existence of multiple subunit isoforms encoded by different alpha genes (alphaA and alphaC).

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

26 Ontology Annotations

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41 Parents

Identifier Name Description
GO:0032991 protein-containing complex A stable assembly of two or more macromolecules, i.e. proteins, nucleic acids, carbohydrates or lipids, in which at least one component is a protein and the constituent parts function together.
GO:0005737 cytoplasm The contents of a cell excluding the plasma membrane and nucleus, but including other subcellular structures.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0043227 membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0043226 organelle Organized structure of distinctive morphology and function. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton, and prokaryotic structures such as anammoxosomes and pirellulosomes. Excludes the plasma membrane.
GO:0043229 intracellular organelle Organized structure of distinctive morphology and function, occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, vesicles, ribosomes and the cytoskeleton. Excludes the plasma membrane.
GO:0043231 intracellular membrane-bounded organelle Organized structure of distinctive morphology and function, bounded by a single or double lipid bilayer membrane and occurring within the cell. Includes the nucleus, mitochondria, plastids, vacuoles, and vesicles. Excludes the plasma membrane.
GO:0071944 cell periphery The broad region around and including the plasma membrane of a cell, encompassing the cell cortex (inside the cell), the plasma membrane, and any external encapsulating structures.
GO:0098796 membrane protein complex Any protein complex that is part of a membrane.
GO:0012505 endomembrane system A collection of membranous structures involved in transport within the cell. The main components of the endomembrane system are endoplasmic reticulum, Golgi bodies, vesicles, cell membrane and nuclear envelope. Members of the endomembrane system pass materials through each other or though the use of vesicles.
GO:0016020 membrane A lipid bilayer along with all the proteins and protein complexes embedded in it and attached to it.
GO:0098588 bounding membrane of organelle The lipid bilayer that forms the outer-most layer of an organelle.
GO:0031090 organelle membrane A membrane that is one of the two lipid bilayers of an organelle envelope or the outermost membrane of single membrane bound organelle.
GO:0005886 plasma membrane The membrane surrounding a cell that separates the cell from its external environment. It consists of a phospholipid bilayer and associated proteins.
GO:0098797 plasma membrane protein complex Any protein complex that is part of the plasma membrane.
GO:0031410 cytoplasmic vesicle A vesicle found in the cytoplasm of a cell.
GO:0097708 intracellular vesicle Any vesicle that is part of the intracellular region.
GO:0031982 vesicle Any small, fluid-filled, spherical organelle enclosed by membrane.
GO:0030659 cytoplasmic vesicle membrane The lipid bilayer surrounding a cytoplasmic vesicle.
GO:0012506 vesicle membrane The lipid bilayer surrounding any membrane-bounded vesicle in the cell.
GO:0005905 clathrin-coated pit A part of the endomembrane system in the form of an invagination of a membrane upon which a clathrin coat forms, and that can be converted by vesicle budding into a clathrin-coated vesicle. Coated pits form on the plasma membrane, where they are involved in receptor-mediated selective transport of many proteins and other macromolecules across the cell membrane, in the trans-Golgi network, and on some endosomes.
GO:0030662 coated vesicle membrane The lipid bilayer surrounding a coated vesicle.
GO:0030135 coated vesicle Small membrane-bounded organelle formed by pinching off of a coated region of membrane. Some coats are made of clathrin, whereas others are made from other proteins.
GO:0030665 clathrin-coated vesicle membrane The lipid bilayer surrounding a clathrin-coated vesicle.
GO:0030136 clathrin-coated vesicle A vesicle with a coat formed of clathrin connected to the membrane via one of the clathrin adaptor complexes.
GO:0030139 endocytic vesicle A membrane-bounded intracellular vesicle formed by invagination of the plasma membrane around an extracellular substance. Endocytic vesicles fuse with early endosomes to deliver the cargo for further sorting.
GO:0030117 membrane coat Any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes, and possibly others. They are found associated with membranes on many vesicles as well as other membrane features such as pits and perhaps tubules.
GO:0048475 coated membrane A single or double lipid bilayer with any of several different proteinaceous coats that can associate with membranes. Membrane coats include those formed by clathrin plus an adaptor complex, the COPI and COPII complexes.

44 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
part of GO:0030128 GO:0030122
part of GO:0030132 GO:0030122
is_a GO:0030131 GO:0030122
is_a GO:0098797 GO:0030122
part of GO:0098796 GO:0030122
part of GO:0048475 GO:0030122
part of GO:0098797 GO:0030122
part of GO:0005905 GO:0030122
part of GO:0016020 GO:0030122
is_a GO:0005575 GO:0030122
part of GO:0110165 GO:0030122
part of GO:0005886 GO:0030122
part of GO:0005622 GO:0030122
is_a GO:0030119 GO:0030122
part of GO:0097708 GO:0030122
part of GO:0030120 GO:0030122
part of GO:0031410 GO:0030122
part of GO:0030662 GO:0030122
part of GO:0030125 GO:0030122
part of GO:0030665 GO:0030122
part of GO:0043231 GO:0030122
part of GO:0030666 GO:0030122
part of GO:0030669 GO:0030122
is_a GO:0032991 GO:0030122
part of GO:0030659 GO:0030122
part of GO:0005737 GO:0030122
part of GO:0098588 GO:0030122
part of GO:0045334 GO:0030122
part of GO:0005575 GO:0030122
part of GO:0031090 GO:0030122

2 Synonyms

Name Type
HA2 clathrin adaptor synonym
HA2 synonym