WormMine: GOTerm GO:2000134 negative regulation of G1/S transition of mitotic cell cycle GO

• Namespace: biological_process
• Obsolete: false
• Description: Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.

0 Cross References

1 Data Sets

• GO Annotation data set

1 Ontology

• Name: GO

4 Ontology Annotations

29 Parents

Identifier	Name	Description
GO:0009987	cellular process	Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150	biological_process	A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0065007	biological regulation	Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794	regulation of cellular process	Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789	regulation of biological process	Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0000278	mitotic cell cycle	Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
GO:1903047	mitotic cell cycle process	A process that is part of the mitotic cell cycle.
GO:0022402	cell cycle process	The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
GO:0007049	cell cycle	The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
GO:1901988	negative regulation of cell cycle phase transition	Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.
GO:0044770	cell cycle phase transition	The cell cycle process by which a cell commits to entering the next cell cycle phase.
GO:0048519	negative regulation of biological process	Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0051726	regulation of cell cycle	Any process that modulates the rate or extent of progression through the cell cycle.
GO:0010564	regulation of cell cycle process	Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0045786	negative regulation of cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
GO:0010948	negative regulation of cell cycle process	Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:1901987	regulation of cell cycle phase transition	Any process that modulates the frequency, rate or extent of cell cycle phase transition.
GO:0048523	negative regulation of cellular process	Any process that stops, prevents, or reduces the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0044843	cell cycle G1/S phase transition	The cell cycle process by which a cell in G1 phase commits to S phase.
GO:0000082	G1/S transition of mitotic cell cycle	The mitotic cell cycle transition by which a cell in G1 commits to S phase. The process begins with the build up of G1 cyclin-dependent kinase (G1 CDK), resulting in the activation of transcription of G1 cyclins. The process ends with the positive feedback of the G1 cyclins on the G1 CDK which commits the cell to S phase, in which DNA replication is initiated.
GO:0044772	mitotic cell cycle phase transition	The cell cycle process by which a cell commits to entering the next mitotic cell cycle phase.
GO:0045930	negative regulation of mitotic cell cycle	Any process that stops, prevents or reduces the rate or extent of progression through the mitotic cell cycle.
GO:0007346	regulation of mitotic cell cycle	Any process that modulates the rate or extent of progress through the mitotic cell cycle.
GO:1901991	negative regulation of mitotic cell cycle phase transition	Any process that stops, prevents or reduces the frequency, rate or extent of mitotic cell cycle phase transition.
GO:1901990	regulation of mitotic cell cycle phase transition	Any process that modulates the frequency, rate or extent of mitotic cell cycle phase transition.
GO:2000045	regulation of G1/S transition of mitotic cell cycle	Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
GO:1902806	regulation of cell cycle G1/S phase transition	Any signaling pathway that modulates the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.
GO:2000134	negative regulation of G1/S transition of mitotic cell cycle	Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the mitotic cell cycle.
GO:1902807	negative regulation of cell cycle G1/S phase transition	Any signaling pathway that decreases or inhibits the activity of a cell cycle cyclin-dependent protein kinase to modulate the switch from G1 phase to S phase of the cell cycle.

44 Relations

Relationship	Parent Term . Identifier	Child Term . Identifier
is_a	GO:2000134	GO:0031568
is_a	GO:2000134	GO:0031571
is_a	GO:2000134	GO:0044819
is_a	GO:1902807	GO:2000134
is_a	GO:2000045	GO:2000134
negatively regulates	GO:0000082	GO:2000134
negatively regulates	GO:0000082	GO:2000134
is_a	GO:0065007	GO:2000134
is_a	GO:1901991	GO:2000134
regulates	GO:0000082	GO:2000134
regulates	GO:1903047	GO:2000134
is_a	GO:0010564	GO:2000134
negatively regulates	GO:0009987	GO:2000134
negatively regulates	GO:0044843	GO:2000134
is_a	GO:1901987	GO:2000134
is_a	GO:0045786	GO:2000134
negatively regulates	GO:0007049	GO:2000134
negatively regulates	GO:0008150	GO:2000134
is_a	GO:0010948	GO:2000134
regulates	GO:0044772	GO:2000134
is_a	GO:0048523	GO:2000134
regulates	GO:0044770	GO:2000134
negatively regulates	GO:0022402	GO:2000134
is_a	GO:1901988	GO:2000134
negatively regulates	GO:0000278	GO:2000134
is_a	GO:0050789	GO:2000134
is_a	GO:1901990	GO:2000134
is_a	GO:0065007	GO:2000134
regulates	GO:0009987	GO:2000134
is_a	GO:0008150	GO:2000134

0 Synonyms