WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0031573 mitotic intra-S DNA damage checkpoint signaling GO

Namespace  biological_process Obsolete  false
Description  A mitotic cell cycle checkpoint that slows DNA synthesis in response to DNA damage by the prevention of new origin firing and the stabilization of slow replication fork progression.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

7 Ontology Annotations

Annotation Extension Qualifier
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in

44 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0033554 cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0006974 DNA damage response Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating damage to its DNA from environmental insults or errors during metabolism.
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0000278 mitotic cell cycle Progression through the phases of the mitotic cell cycle, the most common eukaryotic cell cycle, which canonically comprises four successive phases called G1, S, G2, and M and includes replication of the genome and the subsequent segregation of chromosomes into daughter cells. In some variant cell cycles nuclear replication or nuclear division may not be followed by cell division, or G1 and G2 phases may be absent.
GO:1903047 mitotic cell cycle process A process that is part of the mitotic cell cycle.
GO:0022402 cell cycle process The cellular process that ensures successive accurate and complete genome replication and chromosome segregation.
GO:0007049 cell cycle The progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events. Canonically, the cell cycle comprises the replication and segregation of genetic material followed by the division of the cell, but in endocycles or syncytial cells nuclear replication or nuclear division may not be followed by cell division.
GO:0035556 intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
GO:0000075 cell cycle checkpoint signaling A signaling process that controls cell cycle progression by monitoring the integrity of specific cell cycle events. A cell cycle checkpoint begins with detection of deficiencies or defects and ends with signal transduction.
GO:1901988 negative regulation of cell cycle phase transition Any process that stops, prevents or reduces the frequency, rate or extent of cell cycle phase transition.
GO:0044770 cell cycle phase transition The cell cycle process by which a cell commits to entering the next cell cycle phase.
GO:0023052 signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
GO:0048519 negative regulation of biological process Any process that stops, prevents, or reduces the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0051726 regulation of cell cycle Any process that modulates the rate or extent of progression through the cell cycle.
GO:0010564 regulation of cell cycle process Any process that modulates a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0045786 negative regulation of cell cycle Any process that stops, prevents or reduces the rate or extent of progression through the cell cycle.
GO:0010948 negative regulation of cell cycle process Any process that decreases the rate, frequency or extent of a cellular process that is involved in the progression of biochemical and morphological phases and events that occur in a cell during successive cell replication or nuclear replication events.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:1901987 regulation of cell cycle phase transition Any process that modulates the frequency, rate or extent of cell cycle phase transition.

61 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0044773 GO:0031573
happens during GO:0000084 GO:0031573
is_a GO:1903047 GO:0031573
happens during GO:0022403 GO:0031573
occurs in GO:0005622 GO:0031573
is_a GO:0048519 GO:0031573
is_a GO:0007093 GO:0031573
part of GO:0007049 GO:0031573
happens during GO:0051320 GO:0031573
is_a GO:0042770 GO:0031573
is_a GO:1901987 GO:0031573
negatively regulates GO:0007049 GO:0031573
negatively regulates GO:0009987 GO:0031573
is_a GO:0022402 GO:0031573
is_a GO:1901988 GO:0031573
part of GO:0009987 GO:0031573
is_a GO:0010948 GO:0031573
negatively regulates GO:0022402 GO:0031573
part of GO:0065007 GO:0031573
regulates GO:0044770 GO:0031573
is_a GO:0031570 GO:0031573
occurs in GO:0005575 GO:0031573
is_a GO:0006950 GO:0031573
is_a GO:0009987 GO:0031573
is_a GO:0045930 GO:0031573
regulates GO:0009987 GO:0031573
regulates GO:0007049 GO:0031573
is_a GO:0007165 GO:0031573
is_a GO:0065007 GO:0031573
is_a GO:0048523 GO:0031573

5 Synonyms

Name Type
GO:0072428 alt_id
mitotic intra-S DNA damage checkpoint synonym
signal transduction involved in intra-S DNA damage checkpoint synonym
S-phase checkpoint synonym
intra-S DNA damage checkpoint synonym