WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0032933 SREBP signaling pathway GO

Namespace  biological_process Obsolete  false
Description  The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.

0 Cross References

1 Data Sets

Name URL
GO Annotation data set  

1 Ontology

Name
GO

10 Ontology Annotations

Annotation Extension Qualifier
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in
  involved_in

20 Parents

Identifier Name Description
GO:0009987 cellular process Any process that is carried out at the cellular level, but not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0051716 cellular response to stimulus Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus by a cell and ends with a change in state or activity or the cell.
GO:0050896 response to stimulus Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus. The process begins with detection of the stimulus and ends with a change in state or activity or the cell or organism.
GO:0006950 response to stress Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a disturbance in organismal or cellular homeostasis, usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0033554 cellular response to stress Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating the organism is under stress. The stress is usually, but not necessarily, exogenous (e.g. temperature, humidity, ionizing radiation).
GO:0005575 cellular_component A location, relative to cellular compartments and structures, occupied by a macromolecular machine. There are three types of cellular components described in the gene ontology: (1) the cellular anatomical entity where a gene product carries out a molecular function (e.g., plasma membrane, cytoskeleton) or membrane-enclosed compartments (e.g., mitochondrion); (2) virion components, where viral proteins act, and (3) the stable macromolecular complexes of which gene product are parts (e.g., the clathrin complex).
GO:0005622 intracellular anatomical structure A component of a cell contained within (but not including) the plasma membrane. In eukaryotes it includes the nucleus and cytoplasm.
GO:0110165 cellular anatomical structure A part of a cellular organism consisting of a material entity with granularity above the level of a protein complex but below that of an anatomical system. Note that cellular organisms exclude viruses.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0050794 regulation of cellular process Any process that modulates the frequency, rate or extent of a cellular process, any of those that are carried out at the cellular level, but are not necessarily restricted to a single cell. For example, cell communication occurs among more than one cell, but occurs at the cellular level.
GO:0050789 regulation of biological process Any process that modulates the frequency, rate or extent of a biological process. Biological processes are regulated by many means; examples include the control of gene expression, protein modification or interaction with a protein or substrate molecule.
GO:0035556 intracellular signal transduction The process in which a signal is passed on to downstream components within the cell, which become activated themselves to further propagate the signal and finally trigger a change in the function or state of the cell.
GO:0023052 signaling The entirety of a process in which information is transmitted within a biological system. This process begins with an active signal and ends when a cellular response has been triggered.
GO:0007165 signal transduction The cellular process in which a signal is conveyed to trigger a change in the activity or state of a cell. Signal transduction begins with reception of a signal (e.g. a ligand binding to a receptor or receptor activation by a stimulus such as light), or for signal transduction in the absence of ligand, signal-withdrawal or the activity of a constitutively active receptor. Signal transduction ends with regulation of a downstream cellular process, e.g. regulation of transcription or regulation of a metabolic process. Signal transduction covers signaling from receptors located on the surface of the cell and signaling via molecules located within the cell. For signaling between cells, signal transduction is restricted to events at and within the receiving cell.
GO:0007154 cell communication Any process that mediates interactions between a cell and its surroundings. Encompasses interactions such as signaling or attachment between one cell and another cell, between a cell and an extracellular matrix, or between a cell and any other aspect of its environment.
GO:0006984 ER-nucleus signaling pathway The series of molecular signals that conveys information from the endoplasmic reticulum to the nucleus, usually resulting in a change in transcriptional regulation.
GO:0006991 response to sterol depletion Any process that results in a change in state or activity of a cell or an organism (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.
GO:0032933 SREBP signaling pathway The series of molecular signals from the endoplasmic reticulum to the nucleus generated as a consequence of decreased levels of one or more sterols (and in some yeast, changes in oxygen levels) and which proceeds through activation of a sterol response element binding transcription factor (SREBP) to result in up-regulation of target gene transcription.
GO:0071501 cellular response to sterol depletion Any process that results in a change in state or activity of a cell (in terms of movement, secretion, enzyme production, gene expression, etc.) as a result of a stimulus indicating deprivation of sterols. Sterols are a group of steroids characterized by the presence of one or more hydroxyl groups and a hydrocarbon side-chain in the molecule.

41 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0006984 GO:0032933
is_a GO:0071501 GO:0032933
regulates GO:0008150 GO:0032933
is_a GO:0065007 GO:0032933
part of GO:0007154 GO:0032933
is_a GO:0007165 GO:0032933
is_a GO:0050789 GO:0032933
is_a GO:0008150 GO:0032933
is_a GO:0051716 GO:0032933
is_a GO:0006950 GO:0032933
is_a GO:0009987 GO:0032933
is_a GO:0050794 GO:0032933
part of GO:0051716 GO:0032933
is_a GO:0033554 GO:0032933
is_a GO:0006991 GO:0032933
is_a GO:0035556 GO:0032933
regulates GO:0009987 GO:0032933
part of GO:0008150 GO:0032933
occurs in GO:0110165 GO:0032933
part of GO:0050789 GO:0032933
occurs in GO:0005622 GO:0032933
part of GO:0023052 GO:0032933
part of GO:0009987 GO:0032933
is_a GO:0050896 GO:0032933
part of GO:0065007 GO:0032933
occurs in GO:0005575 GO:0032933
part of GO:0050896 GO:0032933
regulates GO:0032933 GO:0036316
negatively regulates GO:0032933 GO:0036316
regulates GO:0032933 GO:0038175

23 Synonyms

Name Type
endoplasmic reticulum to nucleus sterol response pathway synonym
activation of sterol regulatory element binding protein target gene transcription synonym
ER to nucleus sterol response pathway synonym
endoplasmic reticulum-nuclear sterol response pathway synonym
positive regulation of sterol regulatory element binding protein target gene transcription synonym
ER-nuclear sterol response pathway synonym
positive regulation of transcription via sterol regulatory element binding synonym
positive regulation of sterol regulatory element binding protein target gene transcription involved in sterol depletion response synonym
SREBP signalling synonym
positive regulation of transcription via sterol regulatory element binding involved in ER-nuclear sterol response pathway synonym
SREBP-mediated signaling pathway synonym
SREBP target gene transcriptional activation synonym
sterol depletion response, SREBP target gene transcriptional activation synonym
SREBP-mediated signalling pathway synonym
sterol response element binding protein signaling pathway synonym
sterol regulatory element binding protein target gene transcriptional activation synonym
up regulation of sterol regulatory element binding protein target gene transcription synonym
stimulation of sterol regulatory element binding protein target gene transcription synonym
upregulation of sterol regulatory element binding protein target gene transcription synonym
up-regulation of sterol regulatory element binding protein target gene transcription synonym
GO:0030967 alt_id
GO:0006994 alt_id
GO:0035104 alt_id