WormMine

WS297

Intermine data mining platform for C. elegans and related nematodes

GO Term : GO:0035229 positive regulation of glutamate-cysteine ligase activity GO

Namespace  biological_process Obsolete  false
Description  Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.

0 Cross References

0 Data Sets

1 Ontology

Name
GO

0 Ontology Annotations

14 Parents

Identifier Name Description
GO:0008150 biological_process A biological process is the execution of a genetically-encoded biological module or program. It consists of all the steps required to achieve the specific biological objective of the module. A biological process is accomplished by a particular set of molecular functions carried out by specific gene products (or macromolecular complexes), often in a highly regulated manner and in a particular temporal sequence.
GO:0003674 molecular_function A molecular process that can be carried out by the action of a single macromolecular machine, usually via direct physical interactions with other molecular entities. Function in this sense denotes an action, or activity, that a gene product (or a complex) performs.
GO:0003824 catalytic activity Catalysis of a biochemical reaction at physiological temperatures. In biologically catalyzed reactions, the reactants are known as substrates, and the catalysts are naturally occurring macromolecular substances known as enzymes. Enzymes possess specific binding sites for substrates, and are usually composed wholly or largely of protein, but RNA that has catalytic activity (ribozyme) is often also regarded as enzymatic.
GO:0065007 biological regulation Any process that modulates a measurable attribute of any biological process, quality or function.
GO:0016874 ligase activity Catalysis of the joining of two molecules, or two groups within a single molecule, using the energy from the hydrolysis of ATP, a similar triphosphate, or a pH gradient.
GO:0050790 regulation of catalytic activity Any process that modulates the activity of an enzyme.
GO:0065009 regulation of molecular function Any process that modulates the frequency, rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0016879 ligase activity, forming carbon-nitrogen bonds Catalysis of the joining of two molecules, or two groups within a single molecule, via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0016881 acid-amino acid ligase activity Catalysis of the ligation of an acid to an amino acid via a carbon-nitrogen bond, with the concomitant hydrolysis of the diphosphate bond in ATP or a similar triphosphate.
GO:0004357 glutamate-cysteine ligase activity Catalysis of the reaction: L-cysteine + L-glutamate + ATP = L-gamma-glutamyl-L-cysteine + ADP + 2 H+ + phosphate.
GO:0043085 positive regulation of catalytic activity Any process that activates or increases the activity of an enzyme.
GO:0044093 positive regulation of molecular function Any process that activates or increases the rate or extent of a molecular function, an elemental biological activity occurring at the molecular level, such as catalysis or binding.
GO:0051351 positive regulation of ligase activity Any process that activates or increases the frequency, rate or extent of ligase activity, the catalysis of the ligation of two substances with concomitant breaking of a diphosphate linkage, usually in a nucleoside triphosphate.
GO:0035229 positive regulation of glutamate-cysteine ligase activity Any process that activates or increases the activity of glutamate-cysteine ligase, typically by lowering its sensitivity to inhibition by glutathione and by increasing its affinity for glutamate.

17 Relations

Relationship
Parent Term . Identifier

Child Term . Identifier
is_a GO:0051351 GO:0035229
is_a GO:0065007 GO:0035229
positively regulates GO:0004357 GO:0035229
positively regulates GO:0004357 GO:0035229
is_a GO:0065007 GO:0035229
is_a GO:0008150 GO:0035229
positively regulates GO:0003674 GO:0035229
is_a GO:0065009 GO:0035229
positively regulates GO:0003824 GO:0035229
regulates GO:0003674 GO:0035229
is_a GO:0043085 GO:0035229
positively regulates GO:0016874 GO:0035229
is_a GO:0044093 GO:0035229
regulates GO:0003824 GO:0035229
positively regulates GO:0016881 GO:0035229
is_a GO:0050790 GO:0035229
positively regulates GO:0016879 GO:0035229

5 Synonyms

Name Type
activation of glutamate-cysteine ligase activity synonym
stimulation of glutamate-cysteine ligase activity synonym
up regulation of glutamate-cysteine ligase activity synonym
up-regulation of glutamate-cysteine ligase activity synonym
upregulation of glutamate-cysteine ligase activity synonym